Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase
about
Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activityThe EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent mannerFunctional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signalingA novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signalingMolecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sitesNck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinaseLigand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cellsIdentification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neuronsInteractions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activationSLAP, a dimeric adapter protein, plays a functional role in T cell receptor signalingSAM as a protein interaction domain involved in developmental regulationPDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptorDifferential regulation of EphA2 in normal and malignant cellsThe role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerThe Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and DiseaseActivation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascadeMultiple signaling interactions of Abl and Arg kinases with the EphB2 receptorRegulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformationLigand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptorThe SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotesDistinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerizationA novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1ARole of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2.The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton.Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes.Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signalingDomain requirements for the Dock adapter protein in growth- cone signaling.SLAP deficiency decreases dsDNA autoantibody productionGrowth factor signaling pathways in vascular development.Minding the gaps to promote thrombus growth and stabilitySin: good or bad? A T lymphocyte perspective.Emerging strategies for EphA2 receptor targeting for cancer therapeutics.Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis.Contact-dependent signaling during the late events of platelet activation.Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.EphA2 as a target for ovarian cancer therapy.
P2860
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P2860
Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@ast
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@en
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@en-gb
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@nl
type
label
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@ast
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@en
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@en-gb
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@nl
prefLabel
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@ast
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@en
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@en-gb
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@nl
P2093
P2860
P356
P1476
Characterization of a novel Sr ...... e Eck receptor tyrosine kinase
@en
P2093
P2860
P304
P356
10.1074/JBC.270.33.19201
P407
P577
1995-08-18T00:00:00Z