Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1
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Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin modelsCytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaquesHuman CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoidsCYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)Developmental regulation and induction of cytochrome P450 2W1, an enzyme expressed in colon tumorsContributions of human enzymes in carcinogen metabolismPhosphorylation of endothelial NOS contributes to simvastatin protection against myocardial no-reflow and infarction in reperfused swine hearts: partially via the PKA signaling pathway.Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm.Molecular cloning and enzymatic characterization of sheep CYP2JEfficient hypoxic activation of the anticancer agent AQ4N by CYP2S1 and CYP2W1.Enhanced bacterial expression of several mammalian cytochrome P450s by codon optimization and chaperone coexpressionExpression of CYP2W1 in colon tumors: regulation by gene methylation.Cytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase.Orphans in the human cytochrome P450 superfamily: approaches to discovering functions and relevance in pharmacology.FXYD2, a γ subunit of Na⁺, K⁺-ATPase, maintains persistent mechanical allodynia induced by inflammation.mRNA distribution and heterologous expression of orphan cytochrome P450 20A1Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse modelMetabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipidsExpression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide.Tumour-specific expression of CYP2W1: its potential as a drug target in cancer therapy.Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Toward Endogenous SubstratesEnzymology of retinoic acid biosynthesis and degradation.Characterization of orphan human cytochromes P450.Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology.Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli.Carbon-carbon bond cleavage in activation of the prodrug nabumetone.Approaches to deorphanization of human and microbial cytochrome P450 enzymes.Extrahepatic metabolism at the body's internal-external interfaces.Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer.Advanced Approaches to Model Xenobiotic Metabolism in Bacterial Genotoxicology In Vitro.The CYP2W1 enzyme: regulation, properties and activation of prodrugs.Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs.CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer.The expression of CYP2W1 in colorectal primary tumors, corresponding lymph node metastases and liver metastases.Identification of Genetic Polymorphisms of CYP2W1 in the Three Main Chinese Ethnicities: Han, Tibetan, and Uighur.Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1.Heterologous expression of human cytochrome P450 2S1 in Escherichia coli and investigation of its role in metabolism of benzo[a]pyrene and ellipticine.Retinoic Acid Synthesis and Degradation.Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivativesReduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1.
P2860
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P2860
Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@ast
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@en
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@en-gb
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@nl
type
label
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@ast
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@en
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@en-gb
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@nl
prefLabel
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@ast
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@en
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@en-gb
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@nl
P2093
P921
P3181
P356
P1476
Recombinant enzymes overexpres ...... y of human cytochrome P450 2S1
@en
P2093
Christal D Sohl
F Peter Guengerich
Tsutomu Shimada
Zhong-Liu Wu
P304
P3181
P356
10.1124/MOL.106.023648
P407
P577
2006-06-01T00:00:00Z