cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein
about
Congruence of tissue expression profiles from Gene Expression Atlas, SAGEmap and TissueInfo databasesAlternatively spliced isoforms of FE65 serve as neuron-specific and non-neuronal markersThe beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocationRegulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding proteinMint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's diseaseFe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expressionThe beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogeneProteolytic processing of Alzheimer's β-amyloid precursor proteinHuman amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluidDAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processingFe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor proteinDexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcriptionFE65 as a link between VLDLR and APP to regulate their trafficking and processingLRP: a multifunctional scavenger and signaling receptorInhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, ToporsAlterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity.The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipidsIdentification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform.FE65 in Alzheimer's disease: neuronal distribution and association with neurofibrillary tanglesThe Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movementSorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellular signaling: its significance for Alzheimer's disease.Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.The physiology of the β-amyloid precursor protein intracellular domain AICD.Mercury-induced crystallization and SAD phasing of the human Fe65-PTB1 domain.Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the amyloid precursor protein intracellular domain.Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.An epigenomic role of Fe65 in the cellular response to DNA damageFE65: Roles beyond amyloid precursor protein processing.Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells.hFE65L influences amyloid precursor protein maturation and secretion.X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion.The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance.Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates.The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.Amyloid precursor protein cross-linking stimulates beta amyloid production and pro-inflammatory cytokine release in monocytic lineage cells.Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in beta-amyloid load.Quantification of protein interaction in living cells by two-photon spectral imaging with fluorescent protein fluorescence resonance energy transfer pair devoid of acceptor bleed-through.Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.
P2860
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P2860
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein
description
1996 nî lūn-bûn
@nan
1996 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
name
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@ast
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@en
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@en-gb
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@nl
type
label
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@ast
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@en
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@en-gb
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@nl
prefLabel
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@ast
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@en
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@en-gb
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@nl
P2093
P921
P356
P1476
cDNA cloning and chromosome ma ...... es with the mouse Fe65 protein
@en
P2093
B L Sopher
C M Disteche
G M Martin
M A Miller
M B Dinulos
P304
P356
10.1093/HMG/5.10.1589
P407
P577
1996-10-01T00:00:00Z