X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion.
about
Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolismAn X11alpha/FSBP complex represses transcription of the GSK3beta gene promoterNovel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolismDeletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's diseaseA role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmissionAmyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta poresModulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocationPDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like proteinMint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's diseaseSynergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolismInteraction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowthMint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network.A new functional screening system for identification of regulators for the generation of amyloid beta-protein.Functions of WW domains in the nucleus.Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in DrosophilaThe cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement.A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor proteinIntracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like.Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.Protein aggregates and dementia: is there a common toxicity?PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration.Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder.RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway.FE65 in Alzheimer's disease: neuronal distribution and association with neurofibrillary tanglesPresenilin function and gamma-secretase activity.HIV-Tat regulates macrophage gene expression in the context of neuroAIDS.RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing.The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidFunctional role of the low-density lipoprotein receptor-related protein in Alzheimer's disease.Novel modulators of amyloid-beta precursor protein processing.Amyloid precursor protein and presenilin involvement in cell signaling.Substrate specificity of gamma-secretase and other intramembrane proteases.The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.Regulation of β cleavage of amyloid precursor proteinGlycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein.Association of AICD and Fe65 with Hirano bodies reduces transcriptional activation and initiation of apoptosis.
P2860
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P2860
X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
X11 interaction with beta-amyl ...... myloid beta-protein secretion.
@en
type
label
X11 interaction with beta-amyl ...... myloid beta-protein secretion.
@en
prefLabel
X11 interaction with beta-amyl ...... myloid beta-protein secretion.
@en
P2093
P2860
P356
P1476
X11 interaction with beta-amyl ...... myloid beta-protein secretion.
@en
P2093
P2860
P304
22351-22357
P356
10.1074/JBC.273.35.22351
P407
P577
1998-08-01T00:00:00Z