Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases
about
Werner SyndromeFunctional and physical interaction between WRN helicase and human replication protein AHuman RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.Nuclear structure in normal and Bloom syndrome cellsPotent inhibition of werner and bloom helicases by DNA minor groove binding drugsWerner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activityPhysical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicasesAsymmetry of DNA replication fork progression in Werner's syndromeCharacterization of the enzymatic activity of hChlR1, a novel human DNA helicaseIdentification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta.Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiaeDirect association of Bloom's syndrome gene product with the human mismatch repair protein MLH1Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalphap53-mediated apoptosis is attenuated in Werner syndrome cellsExpression of topoisomerase IIIalpha in normal and neoplastic tissues determined by immunohistochemistry using a novel monoclonal antibodyWerner protein recruits DNA polymerase delta to the nucleolusMus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiaeMms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase IIThe C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stabilityThe Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs.Mutations in DNA replication genes reduce yeast life span.Role of SGS1 and SLX4 in maintaining rDNA structure in Saccharomyces cerevisiae.Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex.RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complexThe Bloom's syndrome gene product interacts with topoisomerase IIIThe exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome proteinFunctional interaction of p53 and BLM DNA helicase in apoptosisThe processing of Holliday junctions by BLM and WRN helicases is regulated by p53Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51A novel protein interacts with the Werner's syndrome gene product physically and functionallyRole of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cellsThe broken genome: genetic and pharmacologic approaches to breaking DNASubstrate-specific inhibition of RecQ helicaseThe yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci.Redundancy of DNA helicases in p53-mediated apoptosis.Localization of the Bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: comparison with the Werner's syndrome helicase.Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.Large-scale mutagenesis of the yeast genome using a Tn7-derived multipurpose transposon.
P2860
Q21146988-FE083EEA-AD2C-411F-A85F-F96062DC091DQ22010009-F121A2EF-4876-4D93-9FA9-75FF7B72EDFDQ22253320-80B0A227-696A-4419-9DF7-9F0FBC270E0BQ22253976-936EA9A9-E255-44EC-B128-86F1E429D47EQ22254376-44C50A70-060F-448A-86CB-3626BB6BE735Q24291787-590A4D3A-4B82-4AC4-8705-249ABAD46D09Q24305559-9FC4BDBB-5E9A-4E23-8CBD-070A9BA7BDB5Q24311409-100BD2F6-8BED-4BA6-BD08-2DE4B5D644F4Q24515331-EA15322B-85C0-4EE1-82D7-DADB9D588465Q24529924-9FFA54EA-3829-4F99-896D-35F310819D19Q24548169-8BE37B3A-B469-487F-8926-6C50314DA78AQ24555123-719FBB51-7581-4B5C-A747-5C7E424D0D52Q24555494-EED9B298-8046-4712-AE12-74A2955C1513Q24603148-96F14543-7B1E-420C-B54B-7BB0CC535F97Q24644151-39EC5A22-FB67-47FD-A084-AA1A75A86AE8Q24674594-8C7B96FD-8B29-4046-AF7B-E754D4DF3B86Q24684096-7A1EE603-457D-49E2-BEF3-DD80728BC5F0Q24791392-2EBB8084-58F6-46C0-B8CD-30DA658DF368Q24801293-49FBC756-EBFD-49A7-800C-B388D3913DC4Q27930229-3D0B14D4-4B1F-45FC-AE7A-CD1BF53CDC66Q27934618-08696C4A-64D0-468C-8948-CDBE7687886CQ27936801-1C247AC1-9185-4184-9FAE-68739C95BCE2Q27937523-3CE77701-EA53-45D9-861D-20D9BD268F48Q27938674-87656258-8C86-474E-92E1-C85867491536Q27939442-774A2830-47F8-4249-B6A7-B879FC46506EQ28139703-226DA6E7-ECF1-4A1F-BD84-56AE7FFAA5A0Q28155868-0EDDD776-187F-4041-8542-7C84B1DD6527Q28201136-6F8DE873-4CD1-4052-8BC0-5FF1B1D3F988Q28206425-B6F38ACF-23DC-4332-93C8-165297617CD1Q28207894-69EC9E37-B7BE-492C-AE4F-4612A3399F5AQ28212274-35572778-2DBC-4BA4-9B49-55AFC34F7070Q28271011-4A3D1013-F5CA-4F11-B8FB-4F3AD939F777Q28299327-ED158405-8AB4-43A0-AEA6-B328320C3A6FQ28362135-0FA70645-9D0B-4779-8D85-85E0C0CA0FD8Q30448876-19DC9789-285B-474C-9979-D354B22D2EA8Q30477090-CC7F2C77-8182-44CD-BEFB-C1FC933CA1EDQ30816265-B03021F7-72F3-4467-AC79-4CC7FEA5E587Q30983796-EC1B82CB-508C-4792-BC5E-3505B49E1DD9Q30990769-EA29A428-0863-4DBF-B8F6-A0761E90C4D3Q31118668-E21EEE0D-E44E-42E8-9507-A3B186280D38
P2860
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases
description
1998 nî lūn-bûn
@nan
1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Bloom's and Werner's syndrome ...... instability in human diseases
@ast
Bloom's and Werner's syndrome ...... instability in human diseases
@en
Bloom's and Werner's syndrome ...... instability in human diseases
@en-gb
Bloom's and Werner's syndrome ...... instability in human diseases
@nl
type
label
Bloom's and Werner's syndrome ...... instability in human diseases
@ast
Bloom's and Werner's syndrome ...... instability in human diseases
@en
Bloom's and Werner's syndrome ...... instability in human diseases
@en-gb
Bloom's and Werner's syndrome ...... instability in human diseases
@nl
prefLabel
Bloom's and Werner's syndrome ...... instability in human diseases
@ast
Bloom's and Werner's syndrome ...... instability in human diseases
@en
Bloom's and Werner's syndrome ...... instability in human diseases
@en-gb
Bloom's and Werner's syndrome ...... instability in human diseases
@nl
P2093
P2860
P356
P1476
Bloom's and Werner's syndrome ...... instability in human diseases
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.15.8733
P407
P577
1998-07-21T00:00:00Z