Conformational diversity in prion protein variants influences intermolecular beta-sheet formation
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Synthetic prions with novel strain-specified propertiesNMR Structure of the Human Prion Protein with the Pathological Q212P Mutation Reveals Unique Structural FeaturesCrystallographic Studies of Prion Protein (PrP) Segments Suggest How Structural Changes Encoded by Polymorphism at Residue 129 Modulate Susceptibility to Human Prion DiseaseStructural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphismGlobular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversionSelenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicityStructural and dynamic properties of the human prion protein.Diverse effects on the native β-sheet of the human prion protein due to disease-associated mutations.Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding.The landscape of the prion protein's structural response to mutation revealed by principal component analysis of multiple NMR ensemblesInfluence of pH on the human prion protein: insights into the early steps of misfolding.Molecular biology and pathology of prion strains in sporadic human prion diseases.Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra.Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.Requirements for mutant and wild-type prion protein misfolding in vitro.Zinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interfaceProtective V127 prion variant prevents prion disease by interrupting the formation of dimer and fibril from molecular dynamics simulations.Prion protein misfolding, strains, and neurotoxicity: an update from studies on Mammalian prions.The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling ModulesPolymorphism at 129 dictates metastable conformations of the human prion protein N-terminal β-sheet.Biochemical and strain properties of CJD prions: complexity versus simplicity.Allosteric function and dysfunction of the prion protein.Early structural features in mammalian prion conformation conversion.The part of a long beta hairpin from the scrapie form of the human prion protein is reconstructed in the synthetic CC36 protein.Fatal Familial Insomnia: Clinical Aspects and Molecular Alterations.Changing the solvent accessibility of the prion protein disulfide bond markedly influences its trafficking and effect on cell function.Molecular dynamics studies on the buffalo prion protein.Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviorsNormal modes of prion proteins: from native to infectious particleEpitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases.Distinct effects of mutations on biophysical properties of human prion protein monomers and oligomers.Detailed computational analysis revealed mutation V210I on PrP induced conformational conversion on β2-α2 loop and α2-α3.The Evolutionary unZIPping of a Dimerization Motif—A Comparison of ZIP and PrP Architectures.Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease
P2860
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P2860
Conformational diversity in prion protein variants influences intermolecular beta-sheet formation
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Conformational diversity in pr ...... molecular beta-sheet formation
@ast
Conformational diversity in pr ...... molecular beta-sheet formation
@en
Conformational diversity in pr ...... molecular beta-sheet formation
@en-gb
Conformational diversity in pr ...... molecular beta-sheet formation
@nl
type
label
Conformational diversity in pr ...... molecular beta-sheet formation
@ast
Conformational diversity in pr ...... molecular beta-sheet formation
@en
Conformational diversity in pr ...... molecular beta-sheet formation
@en-gb
Conformational diversity in pr ...... molecular beta-sheet formation
@nl
altLabel
Conformational diversity in pr ...... termolecular β-sheet formation
@en
prefLabel
Conformational diversity in pr ...... molecular beta-sheet formation
@ast
Conformational diversity in pr ...... molecular beta-sheet formation
@en
Conformational diversity in pr ...... molecular beta-sheet formation
@en-gb
Conformational diversity in pr ...... molecular beta-sheet formation
@nl
P2093
P2860
P921
P356
P1433
P1476
Conformational diversity in pr ...... molecular beta-sheet formation
@en
P2093
Karen J Knaus
Krystyna Surewicz
Lizamma Antony
Seungjoo Lee
Vivien C Yee
Witold K Surewicz
P2860
P304
P356
10.1038/EMBOJ.2009.333
P407
P577
2009-11-19T00:00:00Z