Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets
about
NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptideMutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 functionIdentification of an actin-binding site in p47phox an organizer protein of NADPH oxidaseActivation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phoxBinding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interactionActivation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis.Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domainsEffects of Anaplasma phagocytophila on NADPH oxidase components in human neutrophils and HL-60 cells.Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidasesA p47-phox pseudogene carries the most common mutation causing p47-phox- deficient chronic granulomatous diseasePhosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activationBiochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular systemNeutrophils in innate host defense against Staphylococcus aureus infectionsFull-length p40phox structure suggests a basis for regulation mechanism of its membrane bindingThe phox homology (PX) domain protein interaction network in yeast.Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phoxDeletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activityAnalysis of human phagocyte flavocytochrome b(558) by mass spectrometryCryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox)Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen speciesActivation and assembly of the NADPH oxidase: a structural perspectivep40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domainNaphthalenesulphonamides block neutrophil superoxide production by intact cells and in a cell-free system: is myosin light chain kinase responsible for these effects?The p47phox mouse knock-out model of chronic granulomatous diseaseTetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidasep47phox molecular activation for assembly of the neutrophil NADPH oxidase complex.Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phosphSolution structure of the tandem Src homology 3 domains of p47phox in an autoinhibited form.The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase.Activation of the phagocyte NADPH oxidase protein p47(phox). Phosphorylation controls SH3 domain-dependent binding to p22(phox).Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains.Mapping of functional domains in p47(phox) involved in the activation of NADPH oxidase by "peptide walking".Interaction of two proline-rich sequences of cell adhesion kinase beta with SH3 domains of p130Cas-related proteins and a GTPase-activating protein, Graf.Anionic amphiphile-independent activation of the phagocyte NADPH oxidase in a cell-free system by p47phox and p67phox, both in C terminally truncated forms. Implication for regulatory Src homology 3 domain-mediated interactions.Specificity of p47phox SH3 domain interactions in NADPH oxidase assembly and activation.NADPH oxidase activity is independent of p47phox in vitro.Assembly and activation of the phagocyte NADPH oxidase. Specific interaction of the N-terminal Src homology 3 domain of p47phox with p22phox is required for activation of the NADPH oxidase.
P2860
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P248
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P2860
Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets
description
1994 nî lūn-bûn
@nan
1994 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@ast
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@en
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@en-gb
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@nl
type
label
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@ast
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@en
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@en-gb
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@nl
prefLabel
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@ast
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@en
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@en-gb
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@nl
P2093
P2860
P921
P356
P1476
Assembly of the phagocyte NADP ...... omains to proline-rich targets
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.22.10650
P407
P577
1994-10-25T00:00:00Z