about
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseMolecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinaseInsulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteinsSKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation.Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomesDistinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cellsRIP2 is a novel NF-kappaB-activating and cell death-inducing kinaseA novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heartRoles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activationA novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytesMultiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translationTyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migrationAssociation of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic functionIRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosisCharacterization of a novel member of the DOK family that binds and modulates Abl signalingA novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesionGrb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factorVitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammalsNovel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationObesity and cancer, a case for insulin signalingInsulin receptor signaling in normal and insulin-resistant statesCrystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domainEngagement of Gab1 and Gab2 in erythropoietin signalingInsulin receptor substrate 4 associates with the protein IRASTyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domainErythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activationThe type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient miceGrowth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signalingFunctional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptorsInteraction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activationThe Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cellsSTAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motifThe Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulationCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
P2860
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P2860
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Role of IRS-2 in insulin and cytokine signalling
@ast
Role of IRS-2 in insulin and cytokine signalling
@en
Role of IRS-2 in insulin and cytokine signalling
@en-gb
Role of IRS-2 in insulin and cytokine signalling
@nl
type
label
Role of IRS-2 in insulin and cytokine signalling
@ast
Role of IRS-2 in insulin and cytokine signalling
@en
Role of IRS-2 in insulin and cytokine signalling
@en-gb
Role of IRS-2 in insulin and cytokine signalling
@nl
prefLabel
Role of IRS-2 in insulin and cytokine signalling
@ast
Role of IRS-2 in insulin and cytokine signalling
@en
Role of IRS-2 in insulin and cytokine signalling
@en-gb
Role of IRS-2 in insulin and cytokine signalling
@nl
P2093
P921
P356
P1433
P1476
Role of IRS-2 in insulin and cytokine signalling
@en
P2093
Glasheen E
Myers MG Jr
P2888
P304
P356
10.1038/377173A0
P407
P50
P577
1995-09-01T00:00:00Z
P6179
1022346115