Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol
about
Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profilePotential role of nonstatin cholesterol lowering agentsBroad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and LipogenesisOSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophagesOxysterols and their cellular effectors.Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse.Transcriptional diversity during monocyte to macrophage differentiation.PPARδ activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivityModest diet-induced weight loss reduces macrophage cholesterol efflux to plasma of patients with metabolic syndrome.Macrophage fatty-acid synthase deficiency decreases diet-induced atherosclerosisEnhanced aortic macrophage lipid accumulation and inflammatory response in LDL receptor null mice fed an atherogenic diet.Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI.Lactobacillus acidophilus K301 Inhibits Atherogenesis via Induction of 24 (S), 25-Epoxycholesterol-Mediated ABCA1 and ABCG1 Production and Cholesterol Efflux in Macrophages.Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed miceTreatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage.Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice.25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.Sulfation of 25-hydroxycholesterol regulates lipid metabolism, inflammatory responses, and cell proliferation.Liver X Receptor: Crosstalk Node for the Signaling of Lipid Metabolism, Carbohydrate Metabolism, and Innate Immunity.Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux.Therapeutic strategies to deplete macrophages in atherosclerotic plaques.Practical strategies for modulating foam cell formation and behavior.LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDLThe role of dyslipidemia in diabetic retinopathy.The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast CancerPlasmalogen homeostasis - regulation of plasmalogen biosynthesis and its physiological consequence in mammals.Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis.The oxysterol 24(s),25-epoxycholesterol attenuates human smooth muscle-derived foam cell formation via reduced low-density lipoprotein uptake and enhanced cholesterol effluxLiver X Receptors as Therapeutic Targets for Managing Cholesterol: Implications for Atherosclerosis and Other Inflammatory ConditionsNobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance.Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis.Lipid metabolism fattens up hedgehog signaling.Macrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR(-/-) mice.Quantification of sterol-specific response in human macrophages using automated imaged-based analysis.Andrographolide Inhibits Oxidized LDL-Induced Cholesterol Accumulation and Foam Cell Formation in Macrophages.LAL (Lysosomal Acid Lipase) Promotes Reverse Cholesterol Transport In Vitro and In Vivo.Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling.Endothelin-1 exacerbates lipid accumulation by increasing the protein degradation of the ATP-binding cassette transporter G1 in macrophages.
P2860
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P2860
Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@ast
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@en
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@en-gb
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@nl
type
label
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@ast
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@en
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@en-gb
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@nl
prefLabel
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@ast
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@en
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@en-gb
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@nl
P2093
P2860
P921
P3181
P356
P1476
Selective up-regulation of LXR ...... s of 24(S),25-epoxycholesterol
@en
P2093
Claire L Heslop
Cynthia G Sawyez
Jane Y Edwards
Michael M Beyea
Murray W Huff
P2860
P304
P3181
P356
10.1074/JBC.M611063200
P407
P577
2007-02-23T00:00:00Z