Distinct roles of PTCH2 splice variants in Hedgehog signalling - Wikidata - awgldk - TriplyDB

Distinct roles of PTCH2 splice variants in Hedgehog signalling

Distinct roles of PTCH2 splice variants in Hedgehog signalling

http://www.wikidata.org/entity/Q24530681

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Inhibition of GLI1 gene activation by Patched1 Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia Gene expression profile of empirically delineated classes of unexplained chronic fatigue.Desert hedgehog is a mammal-specific gene expressed during testicular and ovarian development in a marsupial.Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration.Ptch2 mediates the Shh response in Ptch1-/- cells.The hedgehog receptor patched1 in T cells is dispensable for adaptive immunity in mice Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2 The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway The Hedgehog signalling pathway regulates autophagy.SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling Correlations between the Sonic Hedgehog pathway and basal cell carcinoma.Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning.Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina Hedgehog signaling in cancer stem cells: a focus on hematological cancers.Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.A novel first exon of the Patched1 gene is upregulated by Hedgehog signaling resulting in a protein with pathway inhibitory functions.FGF signaling enhances a sonic hedgehog negative feedback loop at the initiation of spinal cord ventral patterning.SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties.A highlight on Sonic hedgehog pathway.

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

http://www.wikidata.org/entity/Q24530681

description

2004 nî lūn-bûn

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2004 թուականի Մարտին հրատարակուած գիտական յօդուած

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2004 թվականի մարտին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Biochemical Journal

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Distinct roles of PTCH2 splice variants in Hedgehog signalling

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Fahimeh Rahnama

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Rune Toftgård

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P2860

Characterization of two patched receptors for the vertebrate hedgehog protein family

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

Activating Smoothened mutations in sporadic basal-cell carcinoma

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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325-334

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10.1042/BJ20031200

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Pt 2

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378

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Peter G Zaphiropoulos

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2004-03-01T00:00:00Z

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14613484

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