FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.
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Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiationIntracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278FThe Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitiTyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its functionUbiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosisNedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and functionSite-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activationThe RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKLDifferential regulation of EphA2 in normal and malignant cellsFibroblast growth factor signaling in skeletal development and diseaseFunctional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancersFibroblast growth factor receptor 1 as a putative therapy target in colorectal cancer.Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasiasDefective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasiaTyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retinaTemporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiationMolecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase.The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking.Role of FGFR2-signaling in the pathogenesis of acne.Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum.The Fibroblast Growth Factor signaling pathwayFibroblast growth factors: biology, function, and application for tissue regeneration.The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor.Simultaneous Inhibition of Estrogen Receptor and the HER2 Pathway in Breast Cancer: Effects of HER2 AbundanceSynergistic interaction between the fibroblast growth factor and bone morphogenetic protein signaling pathways in lens cells.Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model.Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles.Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasiaFibroblast growth factors, old kids on the new block.Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins.Knockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis.Degradation of activated protein kinases by ubiquitination.The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment.Heart genetics in a small package, exploiting the condensed genome of Ciona intestinalis.Docking proteins.Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy.Fibroblast growth factors and their receptors in cancer.Potential dual role of KGF/KGFR as a target option in novel therapeutic strategies for the treatment of cancers and mucosal damages.
P2860
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P2860
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
FRS2 alpha attenuates FGF rece ...... nt of the ubiquitin ligase Cbl
@nl
FRS2 alpha attenuates FGF rece ...... t of the ubiquitin ligase Cbl.
@ast
FRS2 alpha attenuates FGF rece ...... t of the ubiquitin ligase Cbl.
@en
FRS2 alpha attenuates FGF rece ...... t of the ubiquitin ligase Cbl.
@en-gb
type
label
FRS2 alpha attenuates FGF rece ...... nt of the ubiquitin ligase Cbl
@nl
FRS2 alpha attenuates FGF rece ...... t of the ubiquitin ligase Cbl.
@ast
FRS2 alpha attenuates FGF rece ...... t of the ubiquitin ligase Cbl.
@en
FRS2 alpha attenuates FGF rece ...... t of the ubiquitin ligase Cbl.
@en-gb
prefLabel
FRS2 alpha attenuates FGF rece ...... nt of the ubiquitin ligase Cbl
@nl
FRS2 alpha attenuates FGF rece ...... t of the ubiquitin ligase Cbl.
@ast
FRS2 alpha attenuates FGF rece ...... t of the ubiquitin ligase Cbl.
@en
FRS2 alpha attenuates FGF rece ...... t of the ubiquitin ligase Cbl.
@en-gb
P2093
P2860
P356
P1476
FRS2 alpha attenuates FGF rece ...... t of the ubiquitin ligase Cbl.
@en
P2093
Arnold Lee
Betty Lamothe
P2860
P304
P356
10.1073/PNAS.052138899
P407
P577
2002-05-07T00:00:00Z