Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina
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Eye morphogenesis and patterning of the optic vesicleGenetic insights into the mechanisms of Fgf signalingWhich FGF ligands are involved in lens induction?Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotypeFibroblast growth factor receptor signaling is essential for lens fiber cell differentiationEssential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cellsFrs2α enhances fibroblast growth factor-mediated survival and differentiation in lens developmentDistinct requirements for Gab1 in Met and EGF receptor signaling in vivo.Identification of pax6-dependent gene regulatory networks in the mouse lens.Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development.Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development.Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invaginationFRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.Lens induction requires attenuation of ERK signaling by Nf1The cellular and molecular mechanisms of vertebrate lens development.The docking protein FRS2α is a critical regulator of VEGF receptors signalingAn essential role for FGF receptor signaling in lens developmentGenetic and epigenetic mechanisms of gene regulation during lens development.Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptorFGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression.Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.Hyperactivated FRS2α-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients.Deficient FGF signaling causes optic nerve dysgenesis and ocular colobomaRegulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins.The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development.Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasiaThe FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment.Docking proteins.The lens: a classical model of embryonic induction providing new insights into cell determination in early development.Signaling molecules and transcription factors involved in the development of the sympathetic nervous system, with special emphasis on the superior cervical ganglion.Epithelial morphogenesis: the mouse eye as a model system.FRS2α is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblastsCellular and molecular events on the development of mammalian thyroid C cells.Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina.Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.The function of FGF signaling in the lens placodeCdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis.Signaling and Gene Regulatory Networks in Mammalian Lens Development.
P2860
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P2860
Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina
description
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2004
@ast
im Dezember 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/12/07)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/12/07)
@nl
наукова стаття, опублікована в грудні 2004
@uk
name
Tyrosine phosphorylation sites ...... r induction of lens and retina
@ast
Tyrosine phosphorylation sites ...... r induction of lens and retina
@en
Tyrosine phosphorylation sites ...... r induction of lens and retina
@nl
type
label
Tyrosine phosphorylation sites ...... r induction of lens and retina
@ast
Tyrosine phosphorylation sites ...... r induction of lens and retina
@en
Tyrosine phosphorylation sites ...... r induction of lens and retina
@nl
prefLabel
Tyrosine phosphorylation sites ...... r induction of lens and retina
@ast
Tyrosine phosphorylation sites ...... r induction of lens and retina
@en
Tyrosine phosphorylation sites ...... r induction of lens and retina
@nl
P2093
P2860
P356
P1476
Tyrosine phosphorylation sites ...... r induction of lens and retina
@en
P2093
I. Yoshino
J. Schlessinger
M. Shibuya
R. A. Lang
S. Yamamoto
P2860
P304
17144–17149
P356
10.1073/PNAS.0407577101
P407
P577
2004-12-07T00:00:00Z