Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation
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p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activitiesRegulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contextsRole of p120 Ras-GAP in directed cell movementPTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP.Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding siteRAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasionIdentification of Aurora kinases as RasGAP Src homology 3 domain-binding proteinsCharacterization of a brain-specific Rho GTPase-activating protein, p200RhoGAPManipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activityStructural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPasesFunctional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine fingerA RasGAP SH3 peptide aptamer inhibits RasGAP-Aurora interaction and induces caspase-independent tumor cell deathThe function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domainIndependent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and NckEvolutionary expansion of the Ras switch regulatory module in eukaryotesp120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance.Synapsin phosphorylation by SRC tyrosine kinase enhances SRC activity in synaptic vesicles.Characterization of G3BPs: tissue specific expression, chromosomal localisation and rasGAP(120) binding studies.Ras-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain.ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.Anionic amphiphile-independent activation of the phagocyte NADPH oxidase in a cell-free system by p47phox and p67phox, both in C terminally truncated forms. Implication for regulatory Src homology 3 domain-mediated interactions.Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.Phosphorylation of the p190 RhoGAP N-terminal domain by c-Src results in a loss of GTP binding activity.Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration.The human papillomavirus E7 proteins associate with p190RhoGAP and alter its function.Mitotic down-regulation of p190RhoGAP is required for the successful completion of cytokinesisLocalized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration.Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.Cytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein.Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formationp120RasGAP is a mediator of rho pathway activation and tumorigenicity in the DLD1 colorectal cancer cell line.Erk and PI-3 kinase are necessary for collagen binding and actin reorganization in corneal epithelia.Extracellular signal-regulated kinase 1 interacts with and phosphorylates CdGAP at an important regulatory siteControl of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein.Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP.Mechanisms of platelet-derived growth factor-induced chemotaxis.Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton.Chondrocyte-matrix attachment complexes mediate survival and differentiation.
P2860
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P2860
Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation
description
1997 nî lūn-bûn
@nan
1997 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@ast
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@en
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@en-gb
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@nl
type
label
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@ast
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@en
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@en-gb
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@nl
prefLabel
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@ast
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@en
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@en-gb
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@nl
P2860
P356
P1433
P1476
Tandem SH2 binding sites media ...... nism for SH3 domain regulation
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/16.3.473
P407
P577
1997-02-03T00:00:00Z