ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.
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Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomasNaturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitorsLethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathwayWhat a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathwayRegulation of ERBB3/HER3 signaling in cancerBreast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signalingHeregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptorErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1beta1-induced migrationPhosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway.Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations.Complexity of signal transduction mediated by ErbB2: clues to the potential of receptor-targeted cancer therapy.The role of HER2 in cancer therapy and targeted drug deliveryThe E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinomaReceptor tyrosine kinase pathway analysis sheds light on similarities between clear-cell sarcoma and metastatic melanoma.Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase.ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.PTEN Loss Is Associated with Worse Outcome in HER2-Amplified Breast Cancer Patients but Is Not Associated with Trastuzumab Resistance.Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.Wnt/Β-catenin and sex hormone signaling in endometrial homeostasis and cancer.Chemopreventive activity of vitamin E in breast cancer: a focus on γ- and δ-tocopherolA critical role for HER3 in HER2-amplified and non-amplified breast cancers: function of a kinase-dead RTK.Pharmacological strategies to overcome HER2 cross-talk and Trastuzumab resistance.Increased erbB3 promotes erbB2/neu-driven mammary tumor proliferation and co-targeting of erbB2/erbB3 receptors exhibits potent inhibitory effects on breast cancer cellsLethal contractural syndrome type 3 (LCCS3) is caused by a mutation in PIP5K1C, which encodes PIPKI gamma of the phophatidylinsitol pathway.Development and characterisation of a 3D multi-cellular in vitro model of normal human breast: a tool for cancer initiation studiesClinical significance of the integrin α6β4 in human malignancies.Heregulin beta1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells.Role of HER2/HER3 co-receptor in breast carcinogenesis.Decreased LRIG1 in fulvestrant-treated luminal breast cancer cells permits ErbB3 upregulation and increased growth.Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells.GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancerNeuregulin-1 enhances survival of human astrocytic glioma cells.Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinaseHER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation.The role of ErbB3 and its binding partners in breast cancer progression and resistance to hormone and tyrosine kinase directed therapies.Trophic factor expression in phrenic motor neuronsThe ERBB3 receptor in cancer and cancer gene therapyProtein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation
P2860
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P2860
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.
@ast
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.
@en
type
label
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.
@ast
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.
@en
prefLabel
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.
@ast
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.
@en
P2860
P356
P1433
P1476
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase
@en
P2093
P2860
P304
P356
10.1042/BJ3330757
P407
P478
333 ( Pt 3)
P577
1998-08-01T00:00:00Z