A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. - Wikidata - awgldk - TriplyDB

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

http://www.wikidata.org/entity/Q24540067

about

sameAs

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator MDC1 is a mediator of the mammalian DNA damage checkpoint PML colocalizes with and stabilizes the DNA damage response protein TopBP1 Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1 Regulation of TopBP1 oligomerization by Akt/PKB for cell survival Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage.TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival BRCT domains: easy as one, two, three Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation Regulation of E2F1 by BRCT domain-containing protein TopBP1 Modeling the study of DNA damage responses in mice DNA Damage and Pulmonary Hypertension Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control Structural Insights into Recognition of MDC1 by TopBP1 in DNA Replication Checkpoint Control Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1 EDD mediates DNA damage-induced activation of CHK2 Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching ATR: an essential regulator of genome integrity Nuclear RNA-seq of single neurons reveals molecular signatures of activation Viral transport of DNA damage that mimics a stalled replication fork.The Arabidopsis MEI1 gene encodes a protein with five BRCT domains that is involved in meiosis-specific DNA repair events independent of SPO11-induced DSBs.Cut5 is required for the binding of Atr and DNA polymerase alpha to genotoxin-damaged chromatin.The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control.Human TopBP1 ensures genome integrity during normal S phase TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.The 53BP1-EXPAND1 connection in chromatin structure regulation.TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells MDC1 collaborates with TopBP1 in DNA replication checkpoint control.MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication.DNA damage checkpoints in mammals.A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint.

P2860

Q24296094-FE491486-86E7-4DC9-AFF1-C23EF14ECBC2 Q24296229-B3AA4FB5-D449-4608-9D20-377EC9C421D6 Q24303540-52353849-CF4A-49E9-88CF-4EF041CA8302 Q24304951-9EEC4D98-BB2A-437C-BDEA-84B6BC41D675 Q24305051-75BDC2C2-31C9-43E3-9E10-58E9C6DCB77A Q24529923-368D12DB-D275-4DA0-B940-ECDD8932AADD Q24627319-C10F7AC9-DBCF-42E8-BB79-4D98DFFD2EAB Q24635835-DE2AC832-A08D-4940-8371-8A5B51417EAD Q24670580-8DC62CEB-3674-4085-8D13-D7B075051776 Q24682764-5E1B1082-CCB5-40EE-95AC-B3D1FEE8E911 Q26826949-80B43871-FD4F-43D3-B077-96BBF8669A88 Q27005594-3700B24B-2164-4EE4-869E-6A63B5531E62 Q27340183-39891DFC-F7D9-4CF1-9784-2368D1F55B0B Q27666163-7268DD26-1C86-4E83-8B79-3B4D7E4C3EA4 Q27679213-F30D9AB3-135F-4614-99A7-C028D6D3C32C Q27938938-1B40282A-6955-4CAD-B93E-642E7C3F32C4 Q28212996-09E6725E-5934-488A-AB44-FC4AFD44E3CD Q28271191-1AC884C8-89F2-4EDC-B3B6-75129AF3E40A Q28301355-E7F94C41-6409-4C9A-9080-648D9B850F75 Q28508190-F419F142-5D4A-4C75-9E53-B1CDE9DBCA73 Q28586590-20FF90A7-0B17-4A94-BF36-3F13EBA420F7 Q29465549-84E9F528-6288-478B-8AE8-F28B3525910F Q29547883-31A03060-0440-4D2B-8338-9FB5FB2109B3 Q30276962-BFD5B3A9-9DB4-4F95-9BCC-01092B08F22D Q31135876-3DEF4211-9965-4DFB-B33E-7F616709D1FC Q33188042-1E03FED8-3117-4983-9935-8253968B6D23 Q33193630-DD8DA35B-3C5A-4CCC-8082-EBD474FF709A Q33254689-1C28F385-4CF3-459A-99E4-8D347BEDF533 Q33531604-D90C26A6-BD89-42DA-AA03-4B71DF835183 Q34230830-8F84E23B-702A-43D2-861B-10243438DA30 Q34315565-5951B1A8-262D-4DA6-867E-C5BF1068C36A Q34521556-D8288A13-1C59-454F-BB62-12588F7EBB6C Q34568463-16D4F055-FCEC-4260-A3FA-8CD83002C142 Q34825129-C063B4F8-FA2D-4249-884A-B21F2404F43B Q34879712-4AAA99E2-2571-4B96-AF55-8885C47BE028 Q34945684-7C30510C-E1E1-4732-A7A7-6785C0CDC800 Q35965009-90788681-7779-41DE-B34F-D61A4D5A9594 Q36323772-797FC6A3-9522-4266-99EA-ABBDD1DFB226 Q36325437-73850164-F449-4E33-9055-618E58851037 Q36372110-F9EBF6C6-42E6-4FAC-BD4B-F83F63FEAFC3

P2860

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

http://www.wikidata.org/entity/Q24540067

description

2002 nî lūn-bûn

@nan

2002 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival

@nl

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

@ast

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

@en

type

label

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival

@nl

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

@ast

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

@en

prefLabel

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival

@nl

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

@ast

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

@en

P1433

Q24540067-12E47986-5C6F-4C1E-8BD3-E4DF64A44423

P1476

Q24540067-2B6174B0-1444-4DB4-A22B-4C026541DF19

P2093

Q24540067-7727A204-7035-4C16-8FB4-F1CD59B24ED8

Q24540067-CBB51A92-0180-47A9-973F-639B1628C657

Q24540067-E58B74B5-60F2-47AD-A92D-F23B7831D33E

P2860

Q24540067-000D56F1-64DB-4442-A621-301807D514D5

Q24540067-01C2CBD8-D28E-4CB4-A3D0-8DCE0484D181

Q24540067-02B8AB59-3D52-4F5D-8A99-D6EC99D90CDE

Q24540067-093552D9-FDBB-4469-9E82-6BC68CF11AFE

Q24540067-09C22F7E-772B-4526-A195-9E1332F77259

Q24540067-0A7C9DEA-D18F-4EA8-B492-344C077CF398

Q24540067-0ABFFB4A-5FA5-49C4-9811-AD05514BE244

Q24540067-0B624223-B0B6-4A03-B14A-7FA303EA29B4

Q24540067-107D95AE-2B04-4864-88BB-22E4BC176939

Q24540067-11DC3938-DAF9-4B50-8E6C-6AFFDFC71F38

P304

Q24540067-B21E7B0C-EA1A-4555-B99B-11FFB1A94B8B

P31

Q24540067-E7F269EF-1502-4012-B449-47F10A6733FE

P3181

Q24540067-F2823112-140A-42D9-9D49-A8CE4186DBDA

P356

Q24540067-AA07FCE1-E4DA-4B52-A58B-8061FD174EA8

P407

Q24540067-B62BE71E-4460-44EF-B364-15436D5A11A4

P433

Q24540067-95CEEE34-144E-4DF2-B35C-837208D631C5

P478

Q24540067-02A11CD4-66E9-40BC-9F2A-F598E8C1AF40

P577

Q24540067-3BD8911B-F688-4492-9AFE-83401BB2AA0B

P698

Q24540067-4DECDB6A-E5DD-4F3D-839B-149D56B1E6A1

P921

Q24540067-0FD45086-0264-4B0E-9A1D-76BFD2BE88F9

Q24540067-7F32E584-A785-4C88-9933-C6103B6EE714

P932

Q24540067-A7EFBA5F-57DE-411C-9E7F-6B49C9808631

P3181

P356

MCB.22.2.555-566.2002

P1433

Molecular and Cellular Biology

P1476

A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.

@en

P2093

Junjie Chen

http://www.w3.org/2001/XMLSchema#string

Kazuhiko Yamane

http://www.w3.org/2001/XMLSchema#string

Xianglin Wu

http://www.w3.org/2001/XMLSchema#string

P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

A role for ATR in the DNA damage-induced phosphorylation of p53

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

P304

555-566

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

580562

http://www.w3.org/2001/XMLSchema#string

P356

10.1128/MCB.22.2.555-566.2002

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

22

http://www.w3.org/2001/XMLSchema#string

P577

2002-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

11756551

http://www.w3.org/2001/XMLSchema#string

P921

P932

139754

http://www.w3.org/2001/XMLSchema#string