Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization
about
Major histocompatibility complex class II-peptide complexes internalize using a clathrin- and dynamin-independent endocytosis pathwayB lymphocytes secrete antigen-presenting vesiclesCD74 in Kidney DiseaseDirect transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimeraCell surface expression and metabolism of major histocompatibility complex class II invariant chain (CD74) by diverse cell linesThe leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chainsA role for acidic residues in di-leucine motif-based targeting to the endocytic pathwayDecreased endosomal delivery of major histocompatibility complex class II-invariant chain complexes in dynamin-deficient cellsEnhanced expression of CD74 in gastrointestinal cancers and benign tissuesPathways of antigen processing.Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinaseMtv-1 superantigen trafficks independently of major histocompatibility complex class II directly to the B-cell surface by the exocytic pathway.Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartmentsEpstein-Barr virus evades CD4+ T cell responses in lytic cycle through BZLF1-mediated downregulation of CD74 and the cooperation of vBcl-2.Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading.Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus.Functional HLA-DM on the surface of B cells and immature dendritic cells.Strain-dependent variation in the early transcriptional response to CNS injury using a cortical explant system.Dendritic cell maturation and antigen presentation in the absence of invariant chain.CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer.Surrogate target cells expressing surface anti-idiotype antibody for the clinical evaluation of an internalizing CD22-specific antibody.Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence.Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartmentsProtein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable componentsA dominant-negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II major histocompatibility complex (MHC) pathwayIi chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes.Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes.Inhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexesRelated leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein.A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.The monomeric guanosine triphosphatase rab4 controls an essential step on the pathway of receptor-mediated antigen processing in B cellsInvariant chain modulates HLA class II protein recycling and peptide presentation in nonprofessional antigen presenting cellsPresentation of phagocytosed antigens by MHC class I and II.Abundant empty class II MHC molecules on the surface of immature dendritic cells.Extracellular antigen processing and presentation by immature dendritic cells.Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 NefEarly endosomes are required for major histocompatiblity complex class II transport to peptide-loading compartments.MHC class II molecules on the move for successful antigen presentation.
P2860
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P2860
Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization
description
1993 nî lūn-bûn
@nan
1993 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Cell surface HLA-DR-invariant ...... somes by rapid internalization
@ast
Cell surface HLA-DR-invariant ...... somes by rapid internalization
@en
Cell surface HLA-DR-invariant ...... somes by rapid internalization
@nl
type
label
Cell surface HLA-DR-invariant ...... somes by rapid internalization
@ast
Cell surface HLA-DR-invariant ...... somes by rapid internalization
@en
Cell surface HLA-DR-invariant ...... somes by rapid internalization
@nl
prefLabel
Cell surface HLA-DR-invariant ...... somes by rapid internalization
@ast
Cell surface HLA-DR-invariant ...... somes by rapid internalization
@en
Cell surface HLA-DR-invariant ...... somes by rapid internalization
@nl
P2093
P2860
P356
P1476
Cell surface HLA-DR-invariant ...... somes by rapid internalization
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.18.8581
P407
P577
1993-09-15T00:00:00Z