A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.
about
Pmel17 initiates premelanosome morphogenesis within multivesicular bodiesUbiquitination of human leukocyte antigen (HLA)-DM by different membrane-associated RING-CH (MARCH) protein family E3 ligases targets different endocytic pathwaysHLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transportEndocytic clathrin-coated pit formation is independent of receptor internalization signal levelsThe targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membraneHuman leukocyte Antigen-DM polymorphisms in autoimmune diseasesMultiple endocytic signals in the C-terminal tail of the cystic fibrosis transmembrane conductance regulatorDirect vesicular transport of MHC class II molecules from lysosomal structures to the cell surfaceEditing of the HLA-DR-peptide repertoire by HLA-DMThe impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II moleculesSLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates.Pathways of antigen processing.Mechanisms of antigen presentation.A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM.Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR.Intracellular traffic to compartments for MHC class II peptide loading: signals for endosomal and polarized sorting.Intracellular transport and peptide loading of MHC class II molecules: regulation by chaperones and motors.Peptide exchange in MHC molecules.The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation.Roles for trafficking and O-linked glycosylation in the turnover of model cell surface proteins.Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomesEfficient export of the vesicular stomatitis virus G protein from the endoplasmic reticulum requires a signal in the cytoplasmic tail that includes both tyrosine-based and di-acidic motifsFunctional HLA-DM on the surface of B cells and immature dendritic cells.Convergence of non-clathrin- and clathrin-derived endosomes involves Arf6 inactivation and changes in phosphoinositides.Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interactionProtein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable componentsAggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targetingA dominant-negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II major histocompatibility complex (MHC) pathwayADP-Ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes.Right place, right time, right peptide: DO keeps DM focused.ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway.DM determines the cryptic and immunodominant fate of T cell epitopes.Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein.HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR moleculesInteraction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH.Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes.The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments.Suppression of Tetherin-restricting activity upon human immunodeficiency virus type 1 particle release correlates with localization of Vpu in the trans-Golgi network
P2860
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P2860
A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
A lysosomal targeting signal i ...... to MHC class II compartments.
@ast
A lysosomal targeting signal i ...... to MHC class II compartments.
@en
type
label
A lysosomal targeting signal i ...... to MHC class II compartments.
@ast
A lysosomal targeting signal i ...... to MHC class II compartments.
@en
prefLabel
A lysosomal targeting signal i ...... to MHC class II compartments.
@ast
A lysosomal targeting signal i ...... to MHC class II compartments.
@en
P2093
P2860
P356
P1476
A lysosomal targeting signal i ...... M to MHC class II compartments
@en
P2093
E van Donselaar
L Woodruff
P J Peters
P2860
P304
P356
10.1083/JCB.131.2.351
P407
P577
1995-10-01T00:00:00Z