Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes
about
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathwaysRegulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimerp14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasisClinical, laboratory and molecular signs of immunodeficiency in patients with partial oculo-cutaneous albinismDiscovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-IIAmino acids and mTORC1: from lysosomes to diseaseRegulation of mTORC1 by amino acidsNutrient regulation of the mTOR complex 1 signaling pathwayCrystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activationStructural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarityAtg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity.The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling.Membrane recruitment of scaffold proteins drives specific signalingThe novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.Coordinating ERK/MAPK signalling through scaffolds and inhibitorsThe late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.Comprehensive proteomic and transcriptomic characterization of hepatic expression signatures affected in p14 liver conditional knockout mice.Amino acid signalling upstream of mTORNutrient signaling to mTOR and cell growth.LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent mTOR signallingTracing the Archaeal Origins of Eukaryotic Membrane-Trafficking System Building Blocks.Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer riskCoarse-grained versus atomistic simulations: realistic interaction free energies for real proteins.LAMTOR2-mediated modulation of NGF/MAPK activation kinetics during differentiation of PC12 cellsThe development of an affinity evaluation and prediction system by using protein-protein docking simulations and parameter tuning.Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activationControl of cell growth: Rag GTPases in activation of TORC1.Ultrastructural Morphometry Points to a New Role for LAMTOR2 in Regulating the Endo/Lysosomal System.RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.Expression of the Longin domain of TI-VAMP impairs lysosomal secretion and epithelial cell migration.Electrostatic properties of protein-protein complexes.Stability of the endosomal scaffold protein LAMTOR3 depends on heterodimer assembly and proteasomal degradation.Molecular characterization and expression profile of MAP2K1ip1/MP1 gene from tiger shrimp, Penaeus monodon.Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane.Structural basis for the assembly of the Ragulator-Rag GTPase complex.
P2860
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P2860
Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes
description
2004 nî lūn-bûn
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2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2004 թվականի հուլիսին հրատարակված գիտական հոդված
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年學術文章
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name
Crystal structure of the p14/M ...... se signaling to late endosomes
@ast
Crystal structure of the p14/M ...... se signaling to late endosomes
@en
Crystal structure of the p14/M ...... se signaling to late endosomes
@nl
type
label
Crystal structure of the p14/M ...... se signaling to late endosomes
@ast
Crystal structure of the p14/M ...... se signaling to late endosomes
@en
Crystal structure of the p14/M ...... se signaling to late endosomes
@nl
prefLabel
Crystal structure of the p14/M ...... se signaling to late endosomes
@ast
Crystal structure of the p14/M ...... se signaling to late endosomes
@en
Crystal structure of the p14/M ...... se signaling to late endosomes
@nl
P2093
P2860
P50
P921
P356
P1476
Crystal structure of the p14/M ...... se signaling to late endosomes
@en
P2093
Hans D Bartunik
Mariana E G de Araujo
Mirko Hekman
Robert Kurzbauer
Ulf R Rapp
P2860
P304
P356
10.1073/PNAS.0403435101
P407
P577
2004-07-27T00:00:00Z