Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
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Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical ScaffoldsNovel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse ModelStructure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate PotentialFluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase InhibitorsAntimalarial drug discovery - approaches and progress towards new medicines.Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone AntimalarialsSelective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programsCofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screensChemical genetics of Plasmodium falciparumPlasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.Expanding the Antimalarial Drug Arsenal-Now, But How?Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in miceArrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase.Purine and pyrimidine pathways as targets in Plasmodium falciparum.3D-QSAR studies of triazolopyrimidine derivatives of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors using a combination of molecular dynamics, docking, and genetic algorithm-based methods.Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondiiPlasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.Production of recombinant proteins from protozoan parasites.Target identification and validation of novel antimalarials.Novel inhibitors of the Plasmodium falciparum electron transport chain.From crystal to compound: structure-based antimalarial drug discovery.Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era.Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.Synthesis, SAR, and Docking Studies Disclose 2-Arylfuran-1,4-naphthoquinones as In Vitro Antiplasmodial Hits.QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors.Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.Tackling resistance: emerging antimalarials and new parasite targets in the era of elimination
P2860
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P2860
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Identification and characteriz ...... m dihydroorotate dehydrogenase
@en
type
label
Identification and characteriz ...... m dihydroorotate dehydrogenase
@en
prefLabel
Identification and characteriz ...... m dihydroorotate dehydrogenase
@en
P2093
P2860
P50
P356
P1476
Identification and characteriz ...... m dihydroorotate dehydrogenase
@en
P2093
Cassandra A Celatka
Jeffrey D Dvorin
Jon Clardy
Leah M Kennedy
Leila Ross
Martin Kramer
Michael Booker
Vishal Patel
P2860
P304
35078-35085
P356
10.1074/JBC.M804990200
P407
P577
2008-10-08T00:00:00Z