Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase - Wikidata - awgldk - TriplyDB

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

http://www.wikidata.org/entity/Q24564747

about

PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture.The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning Signaling by target of rapamycin proteins in cell growth control Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases mTOR signaling in growth control and disease The TSC1-TSC2 complex: a molecular switchboard controlling cell growth Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol Targeting the mTOR signaling network for cancer therapy Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms Optimizing treatments for lymphangioleiomyomatosis Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin The expanding role of mTOR in cancer cell growth and proliferation Nutrient regulation of the mTOR complex 1 signaling pathway Growth factor signaling to mTORC1 by amino acid-laden macropinosomes.Arsenic trioxide overcomes rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast cancer Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition RAS oncogenes: weaving a tumorigenic web mTOR signaling in tumorigenesis Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6 RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4 Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9 The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

http://www.wikidata.org/entity/Q24564747

description

2004 nî lūn-bûn

@nan

2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

Tumor-promoting phorbol esters ...... ex via p90 ribosomal S6 kinase

@ast

Tumor-promoting phorbol esters ...... ex via p90 ribosomal S6 kinase

@en

Tumor-promoting phorbol esters ...... ex via p90 ribosomal S6 kinase

@nl

type

label

Tumor-promoting phorbol esters ...... ex via p90 ribosomal S6 kinase

@ast

Tumor-promoting phorbol esters ...... ex via p90 ribosomal S6 kinase

@en

Tumor-promoting phorbol esters ...... ex via p90 ribosomal S6 kinase

@nl

prefLabel

Tumor-promoting phorbol esters ...... ex via p90 ribosomal S6 kinase

@ast

Tumor-promoting phorbol esters ...... ex via p90 ribosomal S6 kinase

@en

Tumor-promoting phorbol esters ...... ex via p90 ribosomal S6 kinase

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PNAS.0405659101

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Proceedings of the National Academy of Sciences of the United States of America

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Tumor-promoting phorbol esters ...... ex via p90 ribosomal S6 kinase

@en

P2093

Bryan A Ballif

http://www.w3.org/2001/XMLSchema#string

John Blenis

http://www.w3.org/2001/XMLSchema#string

Rana Anjum

http://www.w3.org/2001/XMLSchema#string

P2860

Rsk1 mediates a MEK-MAP kinase cell survival signal

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity

TSC2 mediates cellular energy response to control cell growth and survival

Correlation between protein and mRNA abundance in yeast

Targeting RAS signalling pathways in cancer therapy

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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13489-13494

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scholarly article

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1503789

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10.1073/PNAS.0405659101

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P433

37

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P478

101

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Philippe P. Roux

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2004-09-01T00:00:00Z

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8369562

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15342917

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518784

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