The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
about
VHL type 2B mutations retain VBC complex form and functionUbiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor proteinIdentification of novel VHL target genes and relationship to hypoxic response pathwaysRegulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasivenessMammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 familyCOMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligaseAn intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor proteinAssociation of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathwayvon Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitinationSynthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau proteinHECT and RING finger families of E3 ubiquitin ligases at a glanceMetabolism of kidney cancer: from the lab to clinical practiceSystemic VHL gene functions and the VHL diseaseIdentification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinomaThe VHL tumor suppressor: master regulator of HIFCellular and molecular basis of deiodinase-regulated thyroid hormone signalingeEF1A is a novel component of the mammalian nuclear protein export machineryCancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancyThe conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradationIdentification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complexActivation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complexStudying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box proteinThe VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activityConjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor functionSequence and structural analysis of BTB domain proteinsThe structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functionsAtlas on substrate recognition subunits of CRL2 E3 ligasesOxygen sensing in retinal health and diseaseRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisMechanisms of chemical carcinogenesis in the kidneysThe metabolic basis of kidney cancerDifferential expression of microRNAs in different disease states.Requirement of ELC1 for RNA polymerase II polyubiquitylation and degradation in response to DNA damage in Saccharomyces cerevisiaeA role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression.Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex.Elongin from Saccharomyces cerevisiae.Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast
P2860
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P2860
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The von Hippel-Lindau tumor-su ...... f the Cdc53 family of proteins
@ast
The von Hippel-Lindau tumor-su ...... f the Cdc53 family of proteins
@en
The von Hippel-Lindau tumor-su ...... f the Cdc53 family of proteins
@nl
type
label
The von Hippel-Lindau tumor-su ...... f the Cdc53 family of proteins
@ast
The von Hippel-Lindau tumor-su ...... f the Cdc53 family of proteins
@en
The von Hippel-Lindau tumor-su ...... f the Cdc53 family of proteins
@nl
prefLabel
The von Hippel-Lindau tumor-su ...... f the Cdc53 family of proteins
@ast
The von Hippel-Lindau tumor-su ...... f the Cdc53 family of proteins
@en
The von Hippel-Lindau tumor-su ...... f the Cdc53 family of proteins
@nl
P2093
P2860
P3181
P356
P1476
The von Hippel-Lindau tumor-su ...... f the Cdc53 family of proteins
@en
P2093
R A Worrell
R D Klausner
W H Burgess
W M Linehan
P2860
P304
P3181
P356
10.1073/PNAS.94.6.2156
P407
P577
1997-03-18T00:00:00Z