Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
about
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathwayThe role of DNA polymerase activity in human non-homologous end joiningIn vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complexDNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repairInteractome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathwaySpecific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNKXLS (c9orf142) is a new component of mammalian DNA double-stranded break repairSUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IVPyrazinamide inhibits trans-translation in Mycobacterium tuberculosisEukaryotic DNA ligases: structural and functional insightsA human XRCC4-XLF complex bridges DNAXRCC4's interaction with XLF is required for coding (but not signal) end joiningGenetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombinationModes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4Structure–function analysis of the 3′ phosphatase component of T4 polynucleotide kinase/phosphataseCrystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJStructure of the Tropomyosin Overlap Complex from Chicken Smooth Muscle: Insight into the Diversity of N-Terminal Recognition,Structures of SAS-6 suggest its organization in centriolesStructural Basis of the 9-Fold Symmetry of CentriolesXRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break RepairNon-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactionsImplication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.Non-homologous end-joining, a sticky affairA composite approach towards a complete model of the myosin rodA noncatalytic function of the ligation complex during nonhomologous end joining.Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineageNHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway.Nonhomologous end joining: a good solution for bad endsGenomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana.Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients.Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF.XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.Cooperative assembly of a protein-DNA filament for nonhomologous end joiningThe high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.XLF regulates filament architecture of the XRCC4·ligase IV complex.Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1.Recognition and repair of chemically heterogeneous structures at DNA endsChoosing the right path: does DNA-PK help make the decision?
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P2860
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
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2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
@ast
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
@en
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
@nl
type
label
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
@ast
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
@en
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
@nl
prefLabel
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
@ast
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
@en
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
@nl
P2093
P2860
P356
P1433
P1476
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/19.22.5962
P407
P577
2000-11-15T00:00:00Z