Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells
about
Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibilityRegulation of ovarian cancer stem cells or tumor-initiating cellsNoncoding RNAs in cancer and cancer stem cellsThe Lin28 cold-shock domain remodels pre-let-7 microRNALet-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinomaDistinct microRNA expression profile in prostate cancer patients with early clinical failure and the impact of let-7 as prognostic marker in high-risk prostate cancerThe miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?Let-7a is a direct EWS-FLI-1 target implicated in Ewing's sarcoma developmentPTEN modulates miR-21 processing via RNA-regulatory protein RNH1.Lin28B is a novel prognostic marker in gastric adenocarcinoma.miR-125b promotes early germ layer specification through Lin28/let-7d and preferential differentiation of mesoderm in human embryonic stem cells.Lin28 mediates paclitaxel resistance by modulating p21, Rb and Let-7a miRNA in breast cancer cells.DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer.Genomic DNA copy-number alterations of the let-7 family in human cancersTowards elucidating the connection between epithelial-mesenchymal transitions and stemnessStability of the hybrid epithelial/mesenchymal phenotype.Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samplesLin28 mediates radiation resistance of breast cancer cells via regulation of caspase, H2A.X and Let-7 signaling.Increased expression of Lin28B associates with poor prognosis in patients with oral squamous cell carcinomaShort loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells.Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approachesCombining TGF-β1 knockdown and miR200c administration to optimize antitumor efficacy of B16F10/GPI-IL-21 vaccine.Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIMAberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancerRegulation of senescence by microRNA biogenesis factorsLin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancerDisturbance of the let-7/LIN28 double-negative feedback loop is associated with radio- and chemo-resistance in non-small cell lung cancer.Lin28B over-expression mediates the repression of let-7 by hepatitis B virus X protein in hepatoma cellsMicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog.Coupling the modules of EMT and stemness: A tunable 'stemness window' modelA cardiac myocyte-restricted Lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1.Lin28b promotes head and neck cancer progression via modulation of the insulin-like growth factor survival pathwayLIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levelsA novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growthThe relationship between Lin28 and the chemotherapy response of gastric cancerRegulation of stem cell populations by microRNAs.The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblastsHuman Lin28 Forms a High-Affinity 1:1 Complex with the 106~363 Cluster miRNA miR-363.
P2860
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P2860
Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Double-negative feedback loop ...... e 1-positive cancer stem cells
@ast
Double-negative feedback loop ...... e 1-positive cancer stem cells
@en
Double-negative feedback loop ...... e 1-positive cancer stem cells
@nl
type
label
Double-negative feedback loop ...... e 1-positive cancer stem cells
@ast
Double-negative feedback loop ...... e 1-positive cancer stem cells
@en
Double-negative feedback loop ...... e 1-positive cancer stem cells
@nl
prefLabel
Double-negative feedback loop ...... e 1-positive cancer stem cells
@ast
Double-negative feedback loop ...... e 1-positive cancer stem cells
@en
Double-negative feedback loop ...... e 1-positive cancer stem cells
@nl
P2093
P2860
P3181
P1433
P1476
Double-negative feedback loop ...... e 1-positive cancer stem cells
@en
P2093
Dionyssios Katsaros
Kathleen Montone
Liping Wang
Ralf Bützow
Shun Liang
Sippy Kaur
Xiaojuan Lin
P2860
P304
P3181
P356
10.1158/0008-5472.CAN-10-2388
P407
P577
2010-11-02T00:00:00Z