Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies - Wikidata - awgldk - TriplyDB

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

http://www.wikidata.org/entity/Q24628801

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LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs The Lin28/let-7 axis regulates glucose metabolism DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors Molecular basis for interaction of let-7 microRNAs with Lin28 Lin28 and let-7 in cell metabolism and cancer The role of miRNAs in regulating gene expression networks MicroRNAs in stress signaling and human disease Classic selective sweeps revealed by massive sequencing in cattle lin-28 controls the succession of cell fate choices via two distinct activities Injuries to appendage extremities and digit tips: A clinical and cellular update Lin28: primal regulator of growth and metabolism in stem cells Lin28 enhances tissue repair by reprogramming cellular metabolism MicroRNAs: their discovery, biogenesis, function and potential use as biomarkers in non-invasive prenatal diagnostics Lin28 sustains early renal progenitors and induces Wilms tumor Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1 Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.Lin28a regulates germ cell pool size and fertility.Two waves of anisotropic growth generate enlarged follicles in the spiny mouse.An assessment of the individual and collective effects of variants on height using twins and a developmentally informative study design.Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes.Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells.Divergent LIN28-mRNA associations result in translational suppression upon the initiation of differentiation.Metabolic requirements for the maintenance of self-renewing stem cells.PKM2: the thread linking energy metabolism reprogramming with epigenetics in cancer LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion Lin28B is a novel prognostic marker in gastric adenocarcinoma.The developmental potential of iPSCs is greatly influenced by reprogramming factor selection Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.Central precocious puberty caused by mutations in the imprinted gene MKRN3.The transcriptional control of female puberty.Association of LIN28B with adult adiposity-related traits in females.Genome wide association study of age at menarche in the Japanese population Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy.

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Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

http://www.wikidata.org/entity/Q24628801

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Lin28a transgenic mice manifes ...... an genetic association studies

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Lin28a transgenic mice manifes ...... an genetic association studies

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Lin28a transgenic mice manifes ...... an genetic association studies

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type

label

Lin28a transgenic mice manifes ...... an genetic association studies

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Lin28a transgenic mice manifes ...... an genetic association studies

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Lin28a transgenic mice manifes ...... an genetic association studies

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Lin28a transgenic mice manifes ...... an genetic association studies

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Lin28a transgenic mice manifes ...... an genetic association studies

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Lin28a transgenic mice manifes ...... an genetic association studies

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Nature Genetics

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Lin28a transgenic mice manifes ...... an genetic association studies

@en

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Ayumu Takeuchi

http://www.w3.org/2001/XMLSchema#string

Gen Shinoda

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Joel N Hirschhorn

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Mark R Palmert

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Mary F Lopez

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Samar Shah

http://www.w3.org/2001/XMLSchema#string

William S Einhorn

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice

A common variant of HMGA2 is associated with adult and childhood height in the general population

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

Selective blockade of microRNA processing by Lin28

Genetic variation in LIN28B is associated with the timing of puberty

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

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626-30

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scholarly article

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1835868

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10.1038/NG.593

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P433

7

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42

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George Q. Daley

Srinivas R Viswanathan

Corinna Grasemann

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2010-07-01T00:00:00Z

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44639327

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1004167536

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20512147

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3069638

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