Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation - Wikidata - awgldk - TriplyDB

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

http://www.wikidata.org/entity/Q24645026

about

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1 Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells Interplay Between Metabolism and Oncogenic Process: Role of microRNAs miRNA biogenesis: biological impact in the development of cancer MYC and the art of microRNA maintenance c-MYC-miRNA circuitry: a central regulator of aggressive B-cell malignancies MicroRNAs that affect prostate cancer: emphasis on prostate cancer in African Americans Noncoding RNAs in cancer and cancer stem cells MicroRNAs in stress signaling and human disease microRNA involvement in human cancer Lin28: primal regulator of growth and metabolism in stem cells Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway A role for Lin28 in primordial germ-cell development and germ-cell malignancy An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates MYC on the path to cancer Hepatic disease biomarkers and liver transplantation: what is the potential utility of microRNAs?N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b.LIN28B confers radio-resistance through the posttranscriptional control of KRAS.Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells.Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.Myc-induced microRNAs integrate Myc-mediated cell proliferation and cell fate.Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation.Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells.Lin28B is a novel prognostic marker in gastric adenocarcinoma.Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth Distinct microRNA expression profiles in prostate cancer stem/progenitor cells and tumor-suppressive functions of let-7.LINE-1 retrotransposons and let-7 miRNA: partners in the pathogenesis of cancer?A novel in vitro three-dimensional retinoblastoma model for evaluating chemotherapeutic drugs.Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.Mechanisms of control of microRNA biogenesis.Complexity of receptor tyrosine kinase signal processing.LIN28B promotes colon cancer migration and recurrence.Towards elucidating the connection between epithelial-mesenchymal transitions and stemness Let-7b is involved in the inflammation and immune responses associated with Helicobacter pylori infection by targeting Toll-like receptor 4.

P2860

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P2860

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

http://www.wikidata.org/entity/Q24645026

description

2009 nî lūn-bûn

@nan

2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

@ast

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

@en

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

@nl

type

label

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

@ast

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

@en

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

@nl

prefLabel

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

@ast

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

@en

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

@nl

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PNAS.0808300106

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

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P2093

Erik A Wentzel

http://www.w3.org/2001/XMLSchema#string

Jason Jung

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Joshua T Mendell

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Lauren R Zeitels

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Michael A Beer

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Michael Dews

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Ping Gao

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Tsung-Cheng Chang

http://www.w3.org/2001/XMLSchema#string

P2860

Prediction and preliminary validation of oncogene regulation by miRNAs

Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Selective blockade of microRNA processing by Lin28

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

miRiad roles for the miR-17-92 cluster in development and disease

Widespread microRNA repression by Myc contributes to tumorigenesis

Suppression of non-small cell lung tumor development by the let-7 microRNA family

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

P304

3384-3389

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scholarly article

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10.1073/PNAS.0808300106

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9

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106

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Andrei Thomas-Tikhonenko

Raghu Chivukula

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2009-02-11T00:00:00Z

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24002881

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19211792

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2651245

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