53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers - Wikidata - awgldk - TriplyDB

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

http://www.wikidata.org/entity/Q24600350

about

FIGNL1-containing protein complex is required for efficient homologous recombination repair The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair Trial watch - inhibiting PARP enzymes for anticancer therapy The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization Applications of DNA integrating elements: Facing the bias bully Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work The utility of transposon mutagenesis for cancer studies in the era of genome editing.Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy PARP inhibitors in the management of breast cancer: current data and future prospects 53BP1: pro choice in DNA repair Metabolic modulation of chromatin: implications for DNA repair and genomic integrity DNA DSB repair pathway choice: an orchestrated handover mechanism Double-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instability DNA double-strand break repair pathway choice and cancer The role of PARP in DNA repair and its therapeutic exploitation Repair of strand breaks by homologous recombination Targeting DNA damage response in cancer therapy Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites.Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.The DNA Damage Response: Making It Safe to Play with Knives 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability A dual role for A-type lamins in DNA double-strand break repair BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds Double strand break repair functions of histone H2AX Expanded roles of the Fanconi anemia pathway in preserving genomic stability RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

http://www.wikidata.org/entity/Q24600350

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

53BP1 loss rescues BRCA1 defic ...... nd BRCA-mutated breast cancers

@ast

53BP1 loss rescues BRCA1 defic ...... nd BRCA-mutated breast cancers

@en

53BP1 loss rescues BRCA1 defic ...... nd BRCA-mutated breast cancers

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type

label

53BP1 loss rescues BRCA1 defic ...... nd BRCA-mutated breast cancers

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53BP1 loss rescues BRCA1 defic ...... nd BRCA-mutated breast cancers

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53BP1 loss rescues BRCA1 defic ...... nd BRCA-mutated breast cancers

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prefLabel

53BP1 loss rescues BRCA1 defic ...... nd BRCA-mutated breast cancers

@ast

53BP1 loss rescues BRCA1 defic ...... nd BRCA-mutated breast cancers

@en

53BP1 loss rescues BRCA1 defic ...... nd BRCA-mutated breast cancers

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Nature Structural & Molecular Biology

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53BP1 loss rescues BRCA1 defic ...... nd BRCA-mutated breast cancers

@en

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Amal Aly

http://www.w3.org/2001/XMLSchema#string

Atul Kulkarni

http://www.w3.org/2001/XMLSchema#string

Bruce G Haffty

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David J Adams

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Hanneke van der Gulden

http://www.w3.org/2001/XMLSchema#string

Jos Jonkers

http://www.w3.org/2001/XMLSchema#string

Jose M Escandell

http://www.w3.org/2001/XMLSchema#string

Madalena Tarsounas

http://www.w3.org/2001/XMLSchema#string

Maria Thanasoula

http://www.w3.org/2001/XMLSchema#string

Mark Pieterse

http://www.w3.org/2001/XMLSchema#string

P2860

Telomere maintenance requires the RAD51D recombination/repair protein

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Repeated observation of breast tumor subtypes in independent gene expression data sets

Cancer susceptibility and the functions of BRCA1 and BRCA2

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

Cell-cycle checkpoints and cancer

X chromosomal abnormalities in basal-like human breast cancer

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688-95

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1749416

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10.1038/NSMB.1831

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6

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17

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Heli Nevanlinna

Johanna Tommiska

Jiřina Bártková

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2010-06-01T00:00:00Z

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44583891

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1032911270

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20453858

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structural biology

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2912507

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