Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy
about
I-SceI-induced gene replacement at a natural locus in embryonic stem cellsA new pathway of translational regulation mediated by eukaryotic initiation factor 3Targeted transgenesisIsolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene familyPDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensationMice with type 2 and 3 Gaucher disease point mutations generated by a single insertion mutagenesis procedureIntroduction of hereditary disease-associated mutations into the beta-amyloid precursor protein gene of mouse embryonic stem cells: a comparison of homologous recombination methodsTRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungsRole of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvationProtamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cellsInsulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL.Utilization of genetically altered animals in the pharmaceutical industry.Rare homologous gene targeting in Histoplasma capsulatum: disruption of the URA5Hc gene by allelic replacement.A gene-targeting approach identifies a function for the first intron in expression of the alpha1(I) collagen gene.Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase.Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio.A novel strategy for the negative selection in mouse embryonic stem cells operated with immunotoxin-mediated cell targeting.Stability of HPRT marker gene expression at different gene-targeted loci: observing and overcoming a position effect.A proposal of a novel experimental procedure to genetically identify disease gene loci in humans.Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signalingCell-specific expression of alpha 1(I) collagen-hGH minigenes in transgenic mice.Differential role of an NF-κB transcriptional response element in endothelial versus intimal cell VCAM-1 expression.Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice.Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy.Genetic approaches for changing the heart and dissecting complex syndromes.Gene targeted ablation of high molecular weight fibroblast growth factor-2.Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteinsFGF2 modulates cardiac remodeling in an isoform- and sex-specific manner.Cardiac development and physiology are modulated by FGF2 in an isoform- and sex-specific manner.Cardiac-specific inducible and conditional gene targeting in mice.Single-copy transgenic mice with chosen-site integration.Overview: generation of gene knockout mice.Engineering subtle targeted mutations into the mouse genome.Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals.Accurate comparison of antibody expression levels by reproducible transgene targeting in engineered recombination-competent CHO cells.Introduction of precise alterations into the mouse genome with high efficiency by stable tag-exchange gene targeting: implications for gene targeting in ES cells.Gene modification via "plug and socket" gene targeting.Genetic knockouts in mice: an update.
P2860
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P2860
Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy
description
1993 nî lūn-bûn
@nan
1993 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Site-directed point mutations ...... ting tag-and-exchange strategy
@ast
Site-directed point mutations ...... ting tag-and-exchange strategy
@en
Site-directed point mutations ...... ting tag-and-exchange strategy
@nl
type
label
Site-directed point mutations ...... ting tag-and-exchange strategy
@ast
Site-directed point mutations ...... ting tag-and-exchange strategy
@en
Site-directed point mutations ...... ting tag-and-exchange strategy
@nl
prefLabel
Site-directed point mutations ...... ting tag-and-exchange strategy
@ast
Site-directed point mutations ...... ting tag-and-exchange strategy
@en
Site-directed point mutations ...... ting tag-and-exchange strategy
@nl
P2093
P2860
P356
P1476
Site-directed point mutations ...... ting tag-and-exchange strategy
@en
P2093
J B Lingrel
T Doetschman
P2860
P304
P356
10.1128/MCB.13.7.4115
P407
P577
1993-07-01T00:00:00Z