TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes - Wikidata - awgldk - TriplyDB

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

http://www.wikidata.org/entity/Q28276964

about

Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state Hax-1 identified as a two-pore channel (TPC)-binding protein A model of lysosomal pH regulation Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease Intracellular calcium channels in protozoa The role of TRPMLs in endolysosomal trafficking and function Intracellular ion channels and cancer Lysosomal membrane proteins and their central role in physiology Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling Upstream deregulation of calcium signaling in Parkinson's disease TPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release.Two-pore channels function in calcium regulation in sea star oocytes and embryos.Regulation of lysosomal ion homeostasis by channels and transporters A lysosome-centered view of nutrient homeostasis Regulation and roles of Ca2+ stores in human sperm Two-pore channels at the intersection of endolysosomal membrane traffic Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+High susceptibility to fatty liver disease in two-pore channel 2-deficient mice Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells TPC: the NAADP discovery channel?Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana Two-pore channels (TPCs): current controversies Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases Comparative genomics explains the evolutionary success of reef-forming corals The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes.Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene.The voltage-gated sodium channel TPC1 confers endolysosomal excitability.The Sac domain-containing phosphoinositide phosphatases: structure, function, and disease Lysosomal exocytosis and lipid storage disorders.AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases.Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis.The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.Lysosomal physiology.

P2860

Q24307004-DD7A6BCC-B1A3-417A-98B3-BD60FB1BB45C Q24315101-DBA385B9-6B82-40BB-B079-4775A3A0787D Q24339389-F3622222-AC37-4453-9721-BEC0FF2A2F8A Q24619305-F57E08BD-35DF-4514-9AB9-76C44FC4EA7C Q26823539-49D43563-2CF6-4DEE-A052-9E96536BD98F Q26852772-2D14C031-1D28-4CCE-B211-41BCEE5AF247 Q26852861-7E5C3E63-6593-4E28-8E94-A8AF08D076A7 Q26864223-2051194C-FD4E-48C8-B731-87AAD5D705A7 Q27008995-573DEA3E-9227-44DF-9FF7-15CAC4C128FF Q27013815-94815D80-9D52-4638-A323-CFDA193CF54C Q27025044-5731DDF0-9E6A-4E33-90CF-EB17EE135B60 Q27026384-E02D962B-7432-4F38-B2D0-293B5ECBF00B Q27306330-ED9FA350-E5F8-448C-96FA-5CF9228D1A51 Q27346606-FF4664F1-C1AC-46AC-89EB-F38405092CC2 Q28069327-43A09454-691D-49EE-9E4B-24E547A3F386 Q28073435-56E63ACE-59AD-4B4C-997B-63C419A5A917 Q28081340-C0A79532-4640-4205-B1DF-28E8C298B0CA Q28085768-9CAFCED4-0CDD-41B9-B091-55E01010927F Q28240502-4B792B5D-A9AB-4E56-BF23-5C460A0F880A Q28246421-54D6D8F4-B66A-474D-B8E9-EFE3F6441C14 Q28260464-A7102748-5604-40FF-BAFC-F887F7B737C0 Q28262391-C6C57EFE-7453-49DE-831B-681F74922769 Q28271341-335151FA-F980-4E21-B4FF-DBA113AD04C6 Q28274013-4BB1153A-1865-41CB-8413-5AD9709DDF20 Q28302766-8CB8CB4B-E640-48B6-92D0-99E16AF405E3 Q28307378-C1231274-40C0-426C-9AA1-35D94555B975 Q28602268-B33A3A32-BA0F-4A3B-ADC4-B22B8A25E518 Q30252649-C6DFE271-957A-4B14-A03B-C9EB0EE6131F Q30537817-47D3D3DF-7A29-4EE0-B192-D854E04D59F3 Q30560982-05AEDC80-58DC-4209-914E-56298EC2A42C Q30696655-D5F6B86F-3FD5-4470-A5C7-9275450AE8FF Q30810815-F75F2B0D-3B20-47DE-B0E7-353A2AFB6790 Q33649917-305F3B61-4E17-452F-9129-27316B2D442D Q33653667-C13FA251-64BE-406C-BEC5-EB2747E3501D Q33700520-B85ADCC8-C8AA-4AC4-B911-9157C420E493 Q33755195-1917135F-531E-451B-95F2-8A5BEBCDC925 Q33764669-BCE27DEF-6F00-46FA-A7C7-DB47D36BBDB9 Q33894915-23F2D889-BE8B-4C9E-A446-D813ADE8167A Q34315702-C79151BC-65CE-4FC1-AFAB-4D7BFBE8F0A9 Q34462083-ED8B8247-AFA4-48E4-B804-5E08E13C231A

P2860

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

http://www.wikidata.org/entity/Q28276964

description

2012 nî lūn-bûn

@nan

2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

TPC proteins are phosphoinosit ...... els in endosomes and lysosomes

@ast

TPC proteins are phosphoinosit ...... els in endosomes and lysosomes

@en

TPC proteins are phosphoinosit ...... els in endosomes and lysosomes

@nl

type

label

TPC proteins are phosphoinosit ...... els in endosomes and lysosomes

@ast

TPC proteins are phosphoinosit ...... els in endosomes and lysosomes

@en

TPC proteins are phosphoinosit ...... els in endosomes and lysosomes

@nl

prefLabel

TPC proteins are phosphoinosit ...... els in endosomes and lysosomes

@ast

TPC proteins are phosphoinosit ...... els in endosomes and lysosomes

@en

TPC proteins are phosphoinosit ...... els in endosomes and lysosomes

@nl

P1433

Q28276964-D7EC1A71-6A29-4838-A466-FA946E7DBC6B

P1476

Q28276964-57426FB2-DF28-4051-86DA-67276B6E9B43

P2093

Q28276964-0DA66B07-2C26-43EE-BAB8-015A62D9D9AE

Q28276964-188B9FBF-46AA-4ACE-BFEB-D4A469BA6A90

Q28276964-50D682AB-DB42-4BB0-8028-5B0C7ABE4FF4

Q28276964-52F54AD1-AA01-4D7F-B71F-D4EE15532859

Q28276964-8C3936F9-1F26-434D-9CE3-B662CCA0860D

Q28276964-9D8E57E6-5DC4-4057-A4B5-30808E5BA155

Q28276964-A74C070C-DA24-4BA4-9DFC-A75B35A0FD16

Q28276964-ACA161AF-93AF-4908-979E-22D06AC4D282

Q28276964-B6328220-C7C7-462E-AF0C-4ACBE86B32D3

Q28276964-B6B63B2B-3ED2-4479-AA12-296E76DD8903

P2860

Q28276964-0FA60AC1-12AE-4150-B01C-8E7DEE12D80C

Q28276964-1053ACC1-EED5-453E-96EC-55CF45929B67

Q28276964-20D86E11-4DC4-49D8-8F84-85D18D35B017

Q28276964-22CFF3B8-C41A-4B10-93F6-95ADAF3AE095

Q28276964-22F0AE87-404D-4821-B565-DB5ED89B2500

Q28276964-2B673913-7305-48DF-AA14-B0EB4F2303D4

Q28276964-2C68F45A-CBF3-4140-A57A-0E0A3751DE08

Q28276964-2F1373BE-C1C7-4004-863D-467B679DDD9B

Q28276964-35C73347-A3F6-4965-8E92-21EB840647BB

Q28276964-3629AD2E-EE0B-4774-9B97-C097E1AB1648

P304

Q28276964-DD4B1674-32D0-4CC0-8DA6-A726F99B1521

P31

Q28276964-8B880030-7A37-4009-95FD-737E5669C8AE

P3181

Q28276964-5C3B59E4-091D-48F6-8F86-2C75B6F376F4

P356

Q28276964-F1F138E5-08B2-4A0C-9281-53FF50BED628

P407

Q28276964-2D433881-4D69-470F-93A2-93541B0F3B64

P433

Q28276964-6BCD7A98-BC10-477A-8925-3FD8DD4E3E76

P478

Q28276964-CEA6180E-FBCE-45B8-AF36-39462FEC12EA

P50

Q28276964-518AAFAC-C44F-4FE4-BD06-3625C49DE486

P577

Q28276964-9A9FE7EC-4D67-408F-B062-338706618993

P5875

Q28276964-D7B04308-8708-49F0-8C0E-4F9A17EC3094

P698

Q28276964-5A166022-C057-4414-BE63-9136DEAE8965

P932

Q28276964-7770D3B1-4A7C-4FFE-B9BD-EA1A37C82CCF

P3181

P356

J.CELL.2012.08.036

P1433

P1476

TPC proteins are phosphoinosit ...... els in endosomes and lysosomes

@en

P2093

Andrew Goschka

http://www.w3.org/2001/XMLSchema#string

Dejian Ren

http://www.w3.org/2001/XMLSchema#string

Dongbiao Shen

http://www.w3.org/2001/XMLSchema#string

Haoxing Xu

http://www.w3.org/2001/XMLSchema#string

Janice Harlow

http://www.w3.org/2001/XMLSchema#string

Michael X Zhu

http://www.w3.org/2001/XMLSchema#string

Mohammad Samie

http://www.w3.org/2001/XMLSchema#string

Xian-Ping Dong

http://www.w3.org/2001/XMLSchema#string

Xiang Wang

http://www.w3.org/2001/XMLSchema#string

Xiaoli Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

NAADP mobilizes calcium from acidic organelles through two-pore channels

Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella.

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

Identification of a chemical probe for NAADP by virtual screening

Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals

Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J

P304

372-83

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

349399

http://www.w3.org/2001/XMLSchema#string

P356

10.1016/J.CELL.2012.08.036

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

151

http://www.w3.org/2001/XMLSchema#string

P50

David E Clapham

P577

2012-10-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

232246139

http://www.w3.org/2001/XMLSchema#string

P698

23063126

http://www.w3.org/2001/XMLSchema#string

P932

3475186

http://www.w3.org/2001/XMLSchema#string