Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. - Wikidata - awgldk - TriplyDB

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.

http://www.wikidata.org/entity/Q34426872

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The hedgehog pathway in triple-negative breast cancer Bromodomain Inhibitor Review: Bromodomain and Extra-terminal Family Protein Inhibitors as a Potential New Therapy in Central Nervous System Tumors Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment Open access chemical probes for epigenetic targets Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions The Role of Hedgehog Signaling in Tumor Induced Bone Disease The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Smoothened variants explain the majority of drug resistance in basal cell carcinoma Functions of BET proteins in erythroid gene expression Targeting BET bromodomains for cancer treatment An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape.Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1 Genetic and molecular alterations across medulloblastoma subgroups Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth.The Hedgehog pathway: role in cell differentiation, polarity and proliferation Small molecule Hedgehog pathway antagonists.Applying ⁸⁹Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins.Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins.Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies.Thin and thick primary cutaneous melanomas reveal distinct patterns of somatic copy number alterations.Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.Erythropoiesis provides a BRD's eye view of BET protein function.BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma.Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling Targeting BET bromodomain proteins in solid tumors Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.Epigenetic pathways and glioblastoma treatment: insights from signaling cascades.Molecular biology of pediatric brain tumors and impact on novel therapies.Hedgehog signaling in cancer stem cells: a focus on hematological cancers.

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Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.

http://www.wikidata.org/entity/Q34426872

description

2014 nî lūn-bûn

@nan

2014 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.

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Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.

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Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.

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Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.

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Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.

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Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.

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Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.

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Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.

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Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.

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Nature Medicine

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Epigenetic targeting of Hedgeh ...... gh BET bromodomain inhibition.

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Anitha Ponnuswami

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Brian A Link

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Brian Nguyen

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Brianna Balansay

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Furong Yu

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Guillame Bergthold

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James E Bradner

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Jean Y Tang

http://www.w3.org/2001/XMLSchema#string

Jun Qi

http://www.w3.org/2001/XMLSchema#string

Michelle Monje

http://www.w3.org/2001/XMLSchema#string

P2860

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

Structure and ligand of a histone acetyltransferase bromodomain

Selective inhibition of BET bromodomains

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Small molecule modulation of Smoothened activity

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists

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732-740

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scholarly article

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10.1038/NM.3613

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7

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20

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2014-06-29T00:00:00Z

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269702390

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1045821094

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24973920

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4108909

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