A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer

A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer

Item
http://www.wikidata.org/entity/Q24633240
Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteinsDynamic dissociating homo-oligomers and the control of protein functionStructural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine  -synthaseStructural basis of regulation and oligomerization of human cystathionine  -synthase, the central enzyme of transsulfurationConformational properties of nine purified cystathionine β-synthase mutants.Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation.Diverse clinical compounds alter the quaternary structure and inhibit the activity of an essential enzymeStructural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionineS-glutathionylation enhances human cystathionine β-synthase activity under oxidative stress conditions.PLP-dependent H(2)S biogenesis.Cystathionine beta-synthase mutants exhibit changes in protein unfolding: conformational analysis of misfolded variants in crude cell extracts.Allosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthase.Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine β-Synthase.Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.Biochemical and computational approaches to improve the clinical treatment of dopa decarboxylase-related diseases: an overviewSurrogate genetics and metabolic profiling for characterization of human disease alleles.Cross-talk between the catalytic core and the regulatory domain in cystathionine β-synthase: study by differential covalent labeling and computational modeling.
P2860

A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer

Item
http://www.wikidata.org/entity/Q24633240
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A pathogenic linked mutation i ...... ization of a full-length dimer
@ast
A pathogenic linked mutation i ...... ization of a full-length dimer
@en
A pathogenic linked mutation i ...... ization of a full-length dimer
@nl
type
label
A pathogenic linked mutation i ...... ization of a full-length dimer
@ast
A pathogenic linked mutation i ...... ization of a full-length dimer
@en
A pathogenic linked mutation i ...... ization of a full-length dimer
@nl
prefLabel
A pathogenic linked mutation i ...... ization of a full-length dimer
@ast
A pathogenic linked mutation i ...... ization of a full-length dimer
@en
A pathogenic linked mutation i ...... ization of a full-length dimer
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
A pathogenic linked mutation i ...... ization of a full-length dimer
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932