Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.
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Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthaseCharacterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteinsNO* binds human cystathionine β-synthase quickly and tightlyStructural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine -synthaseStructure of REV-ERB Ligand-binding Domain Bound to a Porphyrin AntagonistRelative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions.Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes.Purification and characterization of cystathionine β-synthase bearing a cobalt protoporphyrin.Astrocytic redox remodeling by amyloid beta peptideHydrogen sulfide and hemeproteins: knowledge and mysteriesReversible heme-dependent regulation of human cystathionine β-synthase by a flavoprotein oxidoreductase.PLP-dependent H(2)S biogenesis.Folding and activity of mutant cystathionine β-synthase depends on the position and nature of the purification tag: characterization of the R266K CBS mutantAllosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthase.S-Adenosyl-l-methionine Modulates CO and NO• Binding to the Human H2S-generating Enzyme Cystathionine β-Synthase.Detection of reaction intermediates during human cystathionine β-synthase-monitored turnover and H2S production.Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase.Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine β-Synthase.Kinetics of reversible reductive carbonylation of heme in human cystathionine β-synthase.Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy.Inactivation of cystathionine beta-synthase with peroxynitrite.The logic of the hepatic methionine metabolic cycle.Enzymology of H2S biogenesis, decay and signaling.A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?Biochemical and computational approaches to improve the clinical treatment of dopa decarboxylase-related diseases: an overviewInvestigations of low-frequency vibrational dynamics and ligand binding kinetics of cystathionine beta-synthase.Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine β-synthases.Cobalt cystathionine β-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif.Bovine carbonyl lactoperoxidase structure at 2.0Å resolution and infrared spectra as a function of pH.Allosteric control of human cystathionine beta synthase activity by a redox active disulfide bond.Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria.Chemical Biology of H2S Signaling through Persulfidation.
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Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Modulation of the heme electro ...... switching in redox regulation.
@en
Modulation of the heme electro ...... switching in redox regulation.
@nl
type
label
Modulation of the heme electro ...... switching in redox regulation.
@en
Modulation of the heme electro ...... switching in redox regulation.
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prefLabel
Modulation of the heme electro ...... switching in redox regulation.
@en
Modulation of the heme electro ...... switching in redox regulation.
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P2093
P2860
P1476
Modulation of the heme electro ...... switching in redox regulation
@en
P2093
Donald Becker
James Penner-Hahn
Jay Stasser
Peter Madzelan
Ruma Banerjee
Sangita Singh
Thomas G Spiro
P2860
P304
P356
10.1016/J.JINORGBIO.2009.01.009
P577
2009-01-22T00:00:00Z