Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7 - Wikidata - awgldk - TriplyDB

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

http://www.wikidata.org/entity/Q24634424

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Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55 Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6 Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension Nodal morphogens SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation Key role for ubiquitin protein modification in TGFβ signal transduction Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination The role of targeted protein degradation in early neural development Molecular alterations in areas generating fast ripples in an animal model of temporal lobe epilepsy Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity Ubiquitylation, neddylation and the DNA damage response Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)TGFβ signalling in context Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2 Methylation of Smad6 by protein arginine N-methyltransferase 1 CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5 NetSlim: high-confidence curated signaling maps Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades.Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain.Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells Modeling co-expression across species for complex traits: insights to the difference of human and mouse embryonic stem cells Regulation of Ubiquitin Enzymes in the TGF-β Pathway.USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7 Tiul1 and TGIF are Involved in Downregulation of TGFbeta1-induced IgA Isotype Expression.Smad signaling in skeletal development and regeneration.Mechanisms of the epithelial-mesenchymal transition by TGF-beta The regulation of TGF-β/SMAD signaling by protein deubiquitination.Multiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control.Cross-regulation of protein stability by p53 and nuclear receptor SHP.Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression.Regulation of Krüppel-like factor 4 by the anaphase promoting complex pathway is involved in TGF-beta signaling.

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P2860

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

http://www.wikidata.org/entity/Q24634424

description

2003 nî lūn-bûn

@nan

2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

@ast

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

@en

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

@nl

type

label

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

@ast

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

@en

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

@nl

prefLabel

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

@ast

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

@en

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

@nl

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P1433

The EMBO Journal

P1476

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

@en

P2093

Aki Hanyu

http://www.w3.org/2001/XMLSchema#string

Akiyoshi Komuro

http://www.w3.org/2001/XMLSchema#string

Daizo Koinuma

http://www.w3.org/2001/XMLSchema#string

Kohei Miyazono

http://www.w3.org/2001/XMLSchema#string

Kouichiro Goto

http://www.w3.org/2001/XMLSchema#string

Masahiko Shinozaki

http://www.w3.org/2001/XMLSchema#string

Masahito Ebina

http://www.w3.org/2001/XMLSchema#string

Masao Saitoh

http://www.w3.org/2001/XMLSchema#string

Takeshi Imamura

http://www.w3.org/2001/XMLSchema#string

Toshihiro Nukiwa

http://www.w3.org/2001/XMLSchema#string

P2860

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling

P304

6458-6470

http://www.w3.org/2001/XMLSchema#string

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scholarly article

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948887

http://www.w3.org/2001/XMLSchema#string

P356

10.1093/EMBOJ/CDG632

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P407

P433

24

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22

http://www.w3.org/2001/XMLSchema#string

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P577

2003-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

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8975027

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14657019

http://www.w3.org/2001/XMLSchema#string

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291827

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