Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied. - Wikidata - awgldk - TriplyDB

Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied.

Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied.

http://www.wikidata.org/entity/Q24642588

about

Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.Drug Eluting Stents for Malignant Airway Obstruction: A Critical Review of the Literature Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint Paclitaxel: new uses for an old drug.AFM-detected apoptotic changes in morphology and biophysical property caused by paclitaxel in Ishikawa and HeLa cells Cell Division Cycle 6 Promotes Mitotic Slippage and Contributes to Drug Resistance in Paclitaxel-Treated Cancer Cells EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B.Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line.Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis.Mechanisms of the anti-tumor activity of Methyl 2-(-5-fluoro-2-hydroxyphenyl)-1 H-benzo[d]imidazole-5-carboxylate against breast cancer in vitro and in vivo Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel.Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles.Anticancer Alkaloids from Trees: Development into Drugs.Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells.Regulated inactivation of the spindle assembly checkpoint without functional mitotic spindles.Up-regulation of miR-877 induced by paclitaxel inhibits hepatocellular carcinoma cell proliferation though targeting FOXM1.Identification association of drug-disease by using functional gene module for breast cancer.Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization Centrosomes are multifunctional regulators of genome stability Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells USP7 and Daxx regulate mitosis progression and taxane sensitivity by affecting stability of Aurora-A kinase Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible.Mitosis in vertebrates: the G2/M and M/A transitions and their associated checkpoints.Transient defects of mitotic spindle geometry and chromosome segregation errors.Kinesin spindle protein (KSP) inhibitors in combination with chemotherapeutic agents for cancer therapy.Safety and efficacy evaluation of albumin-bound paclitaxel.The Elephant in the Room: The Role of Microtubules in Cancer.Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts.Cdc20 control of cell fate during prolonged mitotic arrest: do Cdc20 protein levels affect cell fate in response to antimitotic compounds?High LET radiation enhances nocodazole Induced cell death in HeLa cells through mitotic catastrophe and apoptosis.The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells.Mitosis: too much of a good thing (can be bad).Paclitaxel-induced aberrant mitosis and mitotic slippage efficiently lead to proliferative death irrespective of canonical apoptosis and p53.

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P2860

Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied.

http://www.wikidata.org/entity/Q24642588

description

2008 nî lūn-bûn

@nan

2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Microtubules do not promote mi ...... checkpoint cannot be satisfied

@nl

Microtubules do not promote mi ...... heckpoint cannot be satisfied.

@ast

Microtubules do not promote mi ...... heckpoint cannot be satisfied.

@en

type

label

Microtubules do not promote mi ...... checkpoint cannot be satisfied

@nl

Microtubules do not promote mi ...... heckpoint cannot be satisfied.

@ast

Microtubules do not promote mi ...... heckpoint cannot be satisfied.

@en

prefLabel

Microtubules do not promote mi ...... checkpoint cannot be satisfied

@nl

Microtubules do not promote mi ...... heckpoint cannot be satisfied.

@ast

Microtubules do not promote mi ...... heckpoint cannot be satisfied.

@en

P1433

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P2860

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Journal of Cell Biology

P1476

Microtubules do not promote mi ...... heckpoint cannot be satisfied.

@en

P2093

Conly L Rieder

http://www.w3.org/2001/XMLSchema#string

Daniela A Brito

http://www.w3.org/2001/XMLSchema#string

Zhenye Yang

http://www.w3.org/2001/XMLSchema#string

P2860

Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores

Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint.

The centromere geometry essential for keeping mitosis error free is controlled by spindle forces

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

The spindle-assembly checkpoint in space and time

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Temporal and spatial control of cyclin B1 destruction in metaphase

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

Extra centrosomes and/or chromosomes prolong mitosis in human cells

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623-629

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scholarly article

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2772032

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10.1083/JCB.200805072

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4

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182

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2008-08-18T00:00:00Z

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23178271

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18710927

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2518701

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