Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine
about
Centriole assembly and the role of Mps1: defensible or dispensable?Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora BStructural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interactionTex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpointProbing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpointAPC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachmentFcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exitNuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitorKinetochore-microtubule interactions: steps towards bi-orientationThe Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint SignalingReconstituting the kinetochore–microtubule interface: what, why, and howLoss of the Greatwall Kinase Weakens the Spindle Assembly CheckpointARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochoresQuantitative assessment of chromosome instability induced through chemical disruption of mitotic progressionMultiple requirements of PLK1 during mouse oocyte maturationCharacterization of ring-like F-actin structure as a mechanical partner for spindle positioning in mitosisMouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential.Aneuploidy-induced cellular stresses limit autophagic degradation.Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrestp12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomesMolecular Insights into Division of Single Human Cancer Cells in On-Chip Transparent Microtubes.Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cellsCrystal Structure of Human Aurora B in Complex with INCENP and VX-680Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity ScreenA TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora BScaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK InhibitorsBub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalingStructure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinaseCnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore.A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.The synthetic purine reversine selectively induces cell death of cancer cellsBCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal CancerQuantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1Structural and functional characterization of the protein kinase Mps1 in Arabidopsis thalianaCDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following MitosisPhosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic SignalingNuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein functionConnecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.
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P2860
Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Dissecting the role of MPS1 in ...... l molecule inhibitor reversine
@ast
Dissecting the role of MPS1 in ...... l molecule inhibitor reversine
@en
Dissecting the role of MPS1 in ...... l molecule inhibitor reversine
@nl
type
label
Dissecting the role of MPS1 in ...... l molecule inhibitor reversine
@ast
Dissecting the role of MPS1 in ...... l molecule inhibitor reversine
@en
Dissecting the role of MPS1 in ...... l molecule inhibitor reversine
@nl
prefLabel
Dissecting the role of MPS1 in ...... l molecule inhibitor reversine
@ast
Dissecting the role of MPS1 in ...... l molecule inhibitor reversine
@en
Dissecting the role of MPS1 in ...... l molecule inhibitor reversine
@nl
P2860
P50
P356
P1476
Dissecting the role of MPS1 in ...... l molecule inhibitor reversine
@en
P2093
Anthony Tighe
P2860
P356
10.1083/JCB.201001036
P407
P577
2010-07-01T00:00:00Z