The mechanism of action of PA-824: Novel insights from transcriptional profiling - Wikidata - awgldk - TriplyDB

The mechanism of action of PA-824: Novel insights from transcriptional profiling

The mechanism of action of PA-824: Novel insights from transcriptional profiling

http://www.wikidata.org/entity/Q24643238

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Combating Tuberculosis Infection: A Forbidding Challenge Nitroimidazoles for the treatment of TB: past, present and future Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects Tuberculosis drug discovery in the post-post-genomic era Rising to the challenge: new therapies for tuberculosis Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824 Lipoamide Channel-Binding Sulfonamides Selectively Inhibit Mycobacterial Lipoamide Dehydrogenase Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide Resistance to first-line anti-TB drugs is associated with reduced nitric oxide susceptibility in Mycobacterium tuberculosis Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway Rv0132c of Mycobacterium tuberculosis encodes a coenzyme F420-dependent hydroxymycolic acid dehydrogenase Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania Antibiotics in the clinical pipeline at the end of 2015.Metabolic Perspectives on Persistence Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism.The chemical biology of new drugs in the development for tuberculosis.Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.Extensively Drug-Resistant Tuberculosis: A Sign of the Times and an Impetus for Antimicrobial Discovery.PA-824 exhibits time-dependent activity in a murine model of tuberculosis.21st century natural product research and drug development and traditional medicines The challenge of new drug discovery for tuberculosis.In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis Impact of Fgd1 and ddn diversity in Mycobacterium tuberculosis complex on in vitro susceptibility to PA-824.Tissue distribution of pretomanid in rat brain via mass spectrometry imaging.Genetic Approaches to Facilitate Antibacterial Drug Development.An unconventional hexacoordinated flavohemoglobin from Mycobacterium tuberculosis.In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosis A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections New drugs and regimens for treatment of TB.Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions.The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis The chemotherapy of tuberculosis: past, present and future.F420H2 Is Required for Phthiocerol Dimycocerosate Synthesis in Mycobacteria.Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery.A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells Energy metabolism and drug efflux in Mycobacterium tuberculosis

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P2860

The mechanism of action of PA-824: Novel insights from transcriptional profiling

http://www.wikidata.org/entity/Q24643238

description

2009 nî lūn-bûn

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2009 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2009 թվականի մայիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

The mechanism of action of PA-824: Novel insights from transcriptional profiling

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

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Communicative & integrative biology

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

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Helena Im Boshoff

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Ujjini Manjunatha

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P2860

OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

Identification of a copper-binding metallothionein in pathogenic mycobacteria

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide

S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense.

Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis.

Tuberculosis - metabolism and respiration in the absence of growth.

Nitric oxide and the respiratory enzyme.

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1413523

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10.4161/CIB.2.3.7926

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3

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Clifton E Barry

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2009-05-01T00:00:00Z

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26704443

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19641733

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bicyclic nitroimidazole

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2717523

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