Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein
about
New insights into an X-traordinary viral proteinSAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesMutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 VprLentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infectionInteraction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentivirusesNonstructural protein 5A is incorporated into hepatitis C virus low-density particle through interaction with core protein and microtubules during intracellular transport.Mutations of the human immunodeficiency virus type 1 p6Gag domain result in reduced retention of Pol proteins during virus assembly.Interaction of human immunodeficiency virus type 2 Vpx and invariant chain.A conserved dileucine-containing motif in p6(gag) governs the particle association of Vpx and Vpr of simian immunodeficiency viruses SIV(mac) and SIV(agm)Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain.Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory proteinp6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing proteaseViral late domainsSubunit-specific analysis of the human immunodeficiency virus type 1 reverse transcriptase in vivo.Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradationHuman immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells.Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.Targeting foreign proteins to human immunodeficiency virus particles via fusion with Vpr and Vpx.Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation.A conserved LXXLF sequence is the major determinant in p6gag required for the incorporation of human immunodeficiency virus type 1 Vpr.Vpr-induced cell cycle arrest is conserved among primate lentiviruses.Inhibition of human and simian immunodeficiency virus protease function by targeting Vpx-protease-mutant fusion protein into viral particlesVpr of simian immunodeficiency virus of African green monkeys is required for replication in macaque macrophages and lymphocytes.Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein.Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells.Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr?Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase AssemblyDegradation of SAMHD1 by Vpx Is Independent of Uncoating.Human immunodeficiency virus type 2 Vpx-Gag interaction.The C-terminal proline-rich tail of human immunodeficiency virus type 2 Vpx is necessary for nuclear localization of the viral preintegration complex in nondividing cells.A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infection.Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins.
P2860
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P2860
Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein
description
1994 nî lūn-bûn
@nan
1994 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Localization of the Vpx packag ...... s type 2 Gag precursor protein
@ast
Localization of the Vpx packag ...... s type 2 Gag precursor protein
@en
Localization of the Vpx packag ...... s type 2 Gag precursor protein
@nl
type
label
Localization of the Vpx packag ...... s type 2 Gag precursor protein
@ast
Localization of the Vpx packag ...... s type 2 Gag precursor protein
@en
Localization of the Vpx packag ...... s type 2 Gag precursor protein
@nl
prefLabel
Localization of the Vpx packag ...... s type 2 Gag precursor protein
@ast
Localization of the Vpx packag ...... s type 2 Gag precursor protein
@en
Localization of the Vpx packag ...... s type 2 Gag precursor protein
@nl
P2093
P2860
P1433
P1476
Localization of the Vpx packag ...... s type 2 Gag precursor protein
@en
P2093
P2860
P304
P407
P577
1994-10-01T00:00:00Z