Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica
about
The 26S proteasome is a multifaceted target for anti-cancer therapiesLessons from the past and charting the future of marine natural products drug discovery and chemical biologyExploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites.Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds.Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamidesProteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin.Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversityTranslating Nature's Library: The Bryostatins and Function-Oriented SynthesisThe marine actinomycete genus Salinispora: a model organism for secondary metabolite discoveryA sea of biosynthesis: marine natural products meet the molecular age.Fundamental reaction pathway and free energy profile of proteasome inhibition by syringolin A (SylA).Nonribosomal Peptide Synthesis-Principles and Prospects.Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trialsFundamental reaction pathway for peptide metabolism by proteasome: insights from first-principles quantum mechanical/molecular mechanical free energy calculationsMarine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development.Inhibitors for the immuno- and constitutive proteasome: current and future trends in drug development.Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A.The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium.Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors.Fundamental reaction pathway and free energy profile for inhibition of proteasome by Epoxomicin.Coupled Biosynthesis of Volatiles and Salinosporamide A in Salinispora tropica.Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations.(S)-4-Trimethylsilyl-3-butyn-2-ol as an auxiliary for stereocontrolled synthesis of salinosporamide analogs with modifications at positions C2 and C5.A(1,3)-strain enabled retention of chirality during bis-cyclization of beta-ketoamides: total synthesis of (-)-salinosporamide A and (-)-homosalinosporamide A.
P2860
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P2860
Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Function-oriented biosynthesis ...... ibitors in Salinispora tropica
@ast
Function-oriented biosynthesis ...... ibitors in Salinispora tropica
@en
Function-oriented biosynthesis ...... ibitors in Salinispora tropica
@nl
type
label
Function-oriented biosynthesis ...... ibitors in Salinispora tropica
@ast
Function-oriented biosynthesis ...... ibitors in Salinispora tropica
@en
Function-oriented biosynthesis ...... ibitors in Salinispora tropica
@nl
prefLabel
Function-oriented biosynthesis ...... ibitors in Salinispora tropica
@ast
Function-oriented biosynthesis ...... ibitors in Salinispora tropica
@en
Function-oriented biosynthesis ...... ibitors in Salinispora tropica
@nl
P2093
P2860
P356
P1476
Function-oriented biosynthesis ...... ibitors in Salinispora tropica
@en
P2093
Andrew J Kale
Chambers C Hughes
Markus Nett
P2860
P304
P356
10.1021/JM901098M
P407
P577
2009-10-01T00:00:00Z