Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy.
about
Four decades of neurodegenerative disease research: how far we have come!Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropicaUbiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathwaysCharacterizing the dynamics of proteasome complexes by proteomics approachesGraded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome PathwayStructural Analysis of Spiro β-Lactone Proteasome InhibitorsStructural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschiiStructural Insights on the Mycobacterium tuberculosis Proteasomal ATPase MpaStructural Models for Interactions between the 20S Proteasome and Its PAN/19S ActivatorsDynamic regulation of archaeal proteasome gate opening as studied by TROSY NMRStructural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasomeFellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasomeCharacterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunitStructure and mechanism of the hexameric MecA-ClpC molecular machineStabilization of an Unusual Salt Bridge in Ubiquitin by the Extra C-Terminal Domain of the Proteasome-Associated Deubiquitinase UCH37 as a Mechanism of Its Exo SpecificityDual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assemblyEnzyme Inhibition by Hydroamination: Design and Mechanism of a Hybrid Carmaphycin-Syringolin Enone Proteasome InhibitorStructure of the ubiquitin-activating enzyme loaded with two ubiquitin moleculesExpression, purification, and crystal structure of N-terminal domains of human ubiquitin-activating enzyme (E1)Proteasomes can degrade a significant proportion of cellular proteins independent of ubiquitination.An inducible chaperone adapts proteasome assembly to stress.Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base.An evolutionarily conserved pathway controls proteasome homeostasisAdditive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN productionGene Expression Analysis of the 26S Proteasome Subunit PSMB4 Reveals Significant Upregulation, Different Expression and Association with Proliferation in Human Pulmonary Neuroendocrine TumoursEvolution of proteasome regulators in eukaryotesDeletion of dop in Mycobacterium smegmatis abolishes pupylation of protein substrates in vivoParkin promotes degradation of the mitochondrial pro-apoptotic ARTS proteinHeat shock proteins in neurodegenerative disorders and agingDistinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates.An evidence-based review of ixazomib citrate and its potential in the treatment of newly diagnosed multiple myeloma.Molecular determinants of MecA as a degradation tag for the ClpCP protease.The vacuole import and degradation pathway utilizes early steps of endocytosis and actin polymerization to deliver cargo proteins to the vacuole for degradationTargeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death.Proteostasis and the aging proteome in health and disease.p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradationEffects of a novel proteasome inhibitor BU-32 on multiple myeloma cells.Characterization, crystallization and preliminary X-ray crystallographic analysis of the Uba5 fragment necessary for high-efficiency activation of Ufm1.Oxidative stress by targeted agents promotes cytotoxicity in hematologic malignancies.Protein homeostasis and aging: The importance of exquisite quality control.
P2860
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P2860
Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Functions of the proteasome: f ...... urveillance to cancer therapy.
@ast
Functions of the proteasome: f ...... urveillance to cancer therapy.
@en
type
label
Functions of the proteasome: f ...... urveillance to cancer therapy.
@ast
Functions of the proteasome: f ...... urveillance to cancer therapy.
@en
prefLabel
Functions of the proteasome: f ...... urveillance to cancer therapy.
@ast
Functions of the proteasome: f ...... urveillance to cancer therapy.
@en
P356
P1476
Functions of the proteasome: f ...... urveillance to cancer therapy.
@en
P2093
A L Goldberg
P356
10.1042/BST0350012
P577
2007-02-01T00:00:00Z