The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma - Wikidata - awgldk - TriplyDB

The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma

The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma

http://www.wikidata.org/entity/Q24648937

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Wnt5a Signaling in Cancer WNT-5A: signaling and functions in health and disease Therapy for BRAFi-Resistant Melanomas: Is WNT5A the Answer?The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction Frizzled homolog proteins, microRNAs and Wnt signaling in cancer Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior.A PTK7/Ror2 Co-Receptor Complex Affects Xenopus Neural Crest Migration Live imaging of Xwnt5A-ROR2 complexes WNT5A encodes two isoforms with distinct functions in cancers A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres Wnt5a inhibits the proliferation and melanogenesis of melanocytes Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.For robust big data analyses: a collection of 150 important pro-metastatic genes WNT5A-ROR2 is induced by inflammatory mediators and is involved in the migration of human ovarian cancer cell line SKOV-3 WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors.Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis.Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma.Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed.Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development.Expression of Ror2 mediates invasive phenotypes in renal cell carcinoma Wnt5a as an effector of TGFβ in mammary development and cancer Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancer Activation of β2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells.Proteomic signatures associated with p53 mutational status in lung adenocarcinoma.Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis High ROR2 expression in tumor cells and stroma is correlated with poor prognosis in pancreatic ductal adenocarcinoma.ROR1 and ROR2 in Human Malignancies: Potentials for Targeted Therapy.Targeting of Noncanonical Wnt5a Signaling by AP-1 Blocker Dominant-Negative Jun When It Inhibits Skin Carcinogenesis.Knockdown of receptor tyrosine kinase-like orphan receptor 2 inhibits cell proliferation and colony formation in osteosarcoma cells by inducing arrest in cell cycle progression.Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines Over-expression of ROR2 and Wnt5a cooperatively correlates with unfavorable prognosis in patients with non-small cell lung cancer.BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance Human Cytomegalovirus Modulates Expression of Noncanonical Wnt Receptor ROR2 To Alter Trophoblast Migration.Regulation of lipid synthesis by the RNA helicase Mov10 controls Wnt5a production.Wnt/β-catenin pathway is regulated by PITX2 homeodomain protein and thus contributes to the proliferation of human ovarian adenocarcinoma cell, SKOV-3.

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The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma

http://www.wikidata.org/entity/Q24648937

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

The orphan tyrosine kinase rec ...... gnaling in metastatic melanoma

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The orphan tyrosine kinase rec ...... gnaling in metastatic melanoma

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The orphan tyrosine kinase rec ...... gnaling in metastatic melanoma

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type

label

The orphan tyrosine kinase rec ...... gnaling in metastatic melanoma

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The orphan tyrosine kinase rec ...... gnaling in metastatic melanoma

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The orphan tyrosine kinase rec ...... gnaling in metastatic melanoma

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The orphan tyrosine kinase rec ...... gnaling in metastatic melanoma

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The orphan tyrosine kinase rec ...... gnaling in metastatic melanoma

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The orphan tyrosine kinase rec ...... gnaling in metastatic melanoma

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The orphan tyrosine kinase rec ...... gnaling in metastatic melanoma

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A D Carter

http://www.w3.org/2001/XMLSchema#string

A D French

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A T Weeraratna

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D D Taub

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F E Indig

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J L Fiori

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M Xu

http://www.w3.org/2001/XMLSchema#string

S K Dissanayake

http://www.w3.org/2001/XMLSchema#string

T C Camilli

http://www.w3.org/2001/XMLSchema#string

P2860

The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon

Wnt5A activates the calpain-mediated cleavage of filamin A

A member of the Frizzled protein family mediating axis induction by Wnt-5A

A novel family of cell surface receptors with tyrosine kinase-like domain

Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases

Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome

Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B

The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway

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34-44

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33405

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10.1038/ONC.2009.305

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1

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29

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Stephen M. Hewitt

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2009-10-05T00:00:00Z

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26868251

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1002911825

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19802008

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2803338

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