A physiological role of the adenosine A3 receptor: sustained cardioprotection
about
The A3 adenosine receptor induces cytoskeleton rearrangement in human astrocytoma cells via a specific action on Rho proteinsPharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cellsPharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell lineNeoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosidesRing-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modificationsConstitutive activation of A(3) adenosine receptors by site-directed mutagenesisDIGE proteome analysis reveals suitability of ischemic cardiac in vitro model for studying cellular response to acute ischemia and regenerationModulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position.Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety.New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kineticsAdenosine-enhanced ischemic preconditioning: adenosine receptor involvement during ischemia and reperfusion.Cardiac purinergic signalling in health and diseaseDesign and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.Adenosine and ischemic preconditioning.Stimulation of adenosine A3 receptors in cerebral ischemia. Neuronal death, recovery, or both?Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor.Adenosine in the treatment of stroke: yes, maybe, or absolutely not?Adenosine and neurotrauma: therapeutic perspectives.A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion.N6-Substituted adenosine derivatives: selectivity, efficacy, and species differences at A3 adenosine receptors.Hide and seek: a comparative autoradiographic in vitro investigation of the adenosine A3 receptorAcute adenosinergic cardioprotection in ischemic-reperfused hearts.Adenosine receptor agonists: from basic medicinal chemistry to clinical development.Mechanisms of induction of adenosine receptor genes and its functional significance.Anti-ischemic effects of multivalent dendrimeric A₃ adenosine receptor agonists in cultured cardiomyocytes and in the isolated rat heart.Introduction to adenosine receptors as therapeutic targets.Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety.(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.Chapter 13. A3 Adenosine Receptors.A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists.Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.Activation and Desensitization of Rat A3-Adenosine Receptors by Selective Adenosine Derivatives and Xanthine-7-Ribosides.Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor.A Food and Drug Administration-Approved Antiviral Agent that Inhibits Adenylyl Cyclase Type 5 Protects the Ischemic Heart Even When Administered after Reperfusion.Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.Gene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A(3) adenosine receptorsAdenosine receptors and reperfusion injury of the heart
P2860
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P2860
A physiological role of the adenosine A3 receptor: sustained cardioprotection
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A physiological role of the adenosine A3 receptor: sustained cardioprotection
@ast
A physiological role of the adenosine A3 receptor: sustained cardioprotection
@en
A physiological role of the adenosine A3 receptor: sustained cardioprotection
@nl
type
label
A physiological role of the adenosine A3 receptor: sustained cardioprotection
@ast
A physiological role of the adenosine A3 receptor: sustained cardioprotection
@en
A physiological role of the adenosine A3 receptor: sustained cardioprotection
@nl
prefLabel
A physiological role of the adenosine A3 receptor: sustained cardioprotection
@ast
A physiological role of the adenosine A3 receptor: sustained cardioprotection
@en
A physiological role of the adenosine A3 receptor: sustained cardioprotection
@nl
P2860
P356
P1476
A physiological role of the adenosine A3 receptor: sustained cardioprotection
@en
P2093
K A Jacobson
P2860
P304
P356
10.1073/PNAS.95.12.6995
P407
P577
1998-06-09T00:00:00Z