Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position.
about
Synthesis and pharmacological characterization of [(125)I]MRS5127, a high affinity, selective agonist radioligand for the A3 adenosine receptorSynthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators.Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors.Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.Purine receptors: GPCR structure and agonist designExploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety.(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonistsDesign of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches.Structural Probing and Molecular Modeling of the A₃ Adenosine Receptor: A Focus on Agonist Binding.Nucleoside modification and concerted mutagenesis of the human A3 adenosine receptor to probe interactions between the 2-position of adenosine analogs and Gln167 in the second extracellular loop.
P2860
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P2860
Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Modulation of adenosine recept ...... substituted at the 2-position.
@ast
Modulation of adenosine recept ...... substituted at the 2-position.
@en
type
label
Modulation of adenosine recept ...... substituted at the 2-position.
@ast
Modulation of adenosine recept ...... substituted at the 2-position.
@en
prefLabel
Modulation of adenosine recept ...... substituted at the 2-position.
@ast
Modulation of adenosine recept ...... substituted at the 2-position.
@en
P2093
P2860
P50
P1476
Modulation of adenosine recept ...... substituted at the 2-position.
@en
P2093
Ariel S Gross
Brian A Harris
Heng T Duong
Michihiro Ohno
Philippe Van Rompaey
Soo-Kyung Kim
Susanna Tchilibon
P2860
P304
P356
10.1016/J.BMC.2004.03.031
P407
P577
2004-06-01T00:00:00Z