High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries
about
Directed Chemical Evolution with an Outsized Genetic CodeWhat is a "DNA-Compatible" Reaction?Interaction-dependent PCR: identification of ligand-target pairs from libraries of ligands and libraries of targets in a single solution-phase experiment.Review article: high-throughput affinity-based technologies for small-molecule drug discovery.Utility of redundant combinatorial libraries in distinguishing high and low quality screening hitsA sequential strand-displacement strategy enables efficient six-step DNA-templated synthesis.Small-molecule discovery from DNA-encoded chemical libraries.The rise, fall and reinvention of combinatorial chemistry.20 years of DNA-encoded chemical libraries.Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries.Discovery of small-molecule interleukin-2 inhibitors from a DNA-encoded chemical library.Affinity-based screening techniques: their impact and benefit to increase the number of high quality leads.Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to fmoc chemistry and a broad array of robust diversity-generating reactions.Streamlining hit discovery and optimization with a yoctoliter scale DNA reactor.Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides.A DNA-templated synthesis of encoded small molecules by DNA self-assembly.Methods for the creation of cyclic Peptide libraries for use in lead discovery.Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library.Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins.DNA-Encoded Dynamic Combinatorial Chemical Libraries.DNA as a versatile chemical component for catalysis, encoding, and stereocontrolAutomated screening for small organic ligands using DNA-encoded chemical libraries.High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections.Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View.Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library.Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries.Aptamer Selection Technology and Recent Advances.Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections.Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures.Poisson Statistics of Combinatorial Library Sampling Predict False Discovery Rates of Screening.Design, preparation, and selection of DNA-encoded dynamic librariesBarcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics.Upgrading Affinity Screening Experiments by Analysis of Next-Generation Sequencing Data.DNA-Encoded Chemical Libraries: A Selection System Based On Endowing Organic Compounds with Amplifiable Information.Optically Encoded Semiconducting Polymer Dots with Single-Wavelength Excitation for Barcoding and Tracking of Single Cells.Exploration of a Au(i)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles.Selection of DNA-encoded small molecule libraries against unmodified and non-immobilized protein targets.Twenty-five Years of DNA-Encoded Chemical Libraries.DNA-encoded chemical libraries: Achievements and remaining challenges.DNA as a Tool for Molecular Discovery
P2860
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P2860
High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
High-throughput sequencing all ...... DNA-encoded chemical libraries
@ast
High-throughput sequencing all ...... DNA-encoded chemical libraries
@en
High-throughput sequencing all ...... DNA-encoded chemical libraries
@nl
type
label
High-throughput sequencing all ...... DNA-encoded chemical libraries
@ast
High-throughput sequencing all ...... DNA-encoded chemical libraries
@en
High-throughput sequencing all ...... DNA-encoded chemical libraries
@nl
prefLabel
High-throughput sequencing all ...... DNA-encoded chemical libraries
@ast
High-throughput sequencing all ...... DNA-encoded chemical libraries
@en
High-throughput sequencing all ...... DNA-encoded chemical libraries
@nl
P2093
P2860
P50
P3181
P356
P1476
High-throughput sequencing all ...... DNA-encoded chemical libraries
@en
P2093
Christoph Dumelin
Luca Mannocci
Markus Leimbacher
Samu Melkko
Yixin Zhang
P2860
P304
P3181
P356
10.1073/PNAS.0805130105
P407
P577
2008-11-18T00:00:00Z