The rise, fall and reinvention of combinatorial chemistry.
about
Molecular docking and structure-based drug design strategiesTowards vast libraries of scaffold-diverse, conformationally constrained oligomers.Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases.Incorporation of heterocycles into the backbone of peptoids to generate diverse peptoid-inspired one bead one compound libraries.Advances in NSAID development: evolution of diclofenac products using pharmaceutical technologyA ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products.A novel piperazine derivative potently induces caspase-dependent apoptosis of cancer cells via inhibition of multiple cancer signaling pathwaysγ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation.The identification of high-affinity G protein-coupled receptor ligands from large combinatorial libraries using multicolor quantum dot-labeled cell-based screening.Network measures for chemical library design.Solid-phase synthesis as a platform for the discovery of new ruthenium complexes for efficient release of photocaged ligands with visible light.Solid-Supported Synthesis and 5-HT7 /5-HT1A Receptor Affinity of Arylpiperazinylbutyl Derivatives of 4,5-dihydro-1,2,4-triazine-6-(1H)-one.γ-AApeptides: Design, Structure, and Applications.A novel small molecule, Rosline, inhibits growth and induces caspase-dependent apoptosis in human lung cancer cells A549 through a reactive oxygen species-dependent mechanism.Chromodomain Ligand Optimization via Target-Class Directed Combinatorial RepurposingCombinatorial chemistry in drug discovery.From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies.Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics.One-Bead-Two-Compound Thioether Bridged Macrocyclic γ-AApeptide Screening Library against EphA2.Exploration of a Au(i)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles.New facile enantio- and diastereo-selective syntheses of (-)-triptonide and (-)-triptolide.A composite element bit design for magnetically encoded microcarriers for future combinatorial chemistry applications
P2860
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P2860
The rise, fall and reinvention of combinatorial chemistry.
description
2011 nî lūn-bûn
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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The rise, fall and reinvention of combinatorial chemistry.
@ast
The rise, fall and reinvention of combinatorial chemistry.
@en
type
label
The rise, fall and reinvention of combinatorial chemistry.
@ast
The rise, fall and reinvention of combinatorial chemistry.
@en
prefLabel
The rise, fall and reinvention of combinatorial chemistry.
@ast
The rise, fall and reinvention of combinatorial chemistry.
@en
P2860
P356
P1476
The rise, fall and reinvention of combinatorial chemistry.
@en
P2093
Thomas Kodadek
P2860
P304
P356
10.1039/C1CC12102B
P407
P577
2011-06-24T00:00:00Z