Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid
about
Enzymes of the cyclooxygenase pathways of prostanoid biosynthesisHuman cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimerEndocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathwaysReciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implicationsCoxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers,Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxibOxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding NetworkRepurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosisInhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofenCharacterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase InhibitorSubstrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activationConservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics.Molecular basis of cyclooxygenase enzymes (COXs) selective inhibitionSubstrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentationPhysical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress.Asymmetric acetylation of the cyclooxygenase-2 homodimer by aspirin and its effects on the oxygenation of arachidonic, eicosapentaenoic, and docosahexaenoic acids.Mitochondrial and Plasma Membrane Citrate Transporters: Discovery of Selective Inhibitors and Application to Structure/Function AnalysisConjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance.Multiple functions of endocannabinoid signaling in the brain.The structure of ibuprofen bound to cyclooxygenase-2.A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase.Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activationConjugation of cisplatin analogues and cyclooxygenase inhibitors to overcome cisplatin resistance.Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2.Human cyclooxygenase-1 activity and its responses to COX inhibitors are allosterically regulated by nonsubstrate fatty acids.Competition and allostery govern substrate selectivity of cyclooxygenase-2.Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activatorPulsed Dipolar Spectroscopy Reveals That Tyrosyl Radicals Are Generated in Both Monomers of the Cyclooxygenase-2 DimerDifferent Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis.Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide.Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2.Back-scattering interferometry: an ultrasensitive method for the unperturbed detection of acetylcholinesterase-inhibitor interactions.Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide TonePre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.
P2860
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P2860
Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Differential sensitivity and m ...... y ibuprofen and mefenamic acid
@ast
Differential sensitivity and m ...... y ibuprofen and mefenamic acid
@en
Differential sensitivity and m ...... y ibuprofen and mefenamic acid
@nl
type
label
Differential sensitivity and m ...... y ibuprofen and mefenamic acid
@ast
Differential sensitivity and m ...... y ibuprofen and mefenamic acid
@en
Differential sensitivity and m ...... y ibuprofen and mefenamic acid
@nl
prefLabel
Differential sensitivity and m ...... y ibuprofen and mefenamic acid
@ast
Differential sensitivity and m ...... y ibuprofen and mefenamic acid
@en
Differential sensitivity and m ...... y ibuprofen and mefenamic acid
@nl
P2093
P2860
P356
P1433
P1476
Differential sensitivity and m ...... y ibuprofen and mefenamic acid
@en
P2093
Carol A Rouzer
Jeffery J Prusakiewicz
Kelsey C Duggan
Lawrence J Marnett
P2860
P304
P356
10.1021/BI900999Z
P407
P577
2009-08-11T00:00:00Z