Cyclooxygenase Allosterism, Fatty Acid-mediated Cross-talk between Monomers of Cyclooxygenase Homodimers.
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Enzymes of the cyclooxygenase pathways of prostanoid biosynthesisHuman cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimerDifferential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acidEndocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathwaysReciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implicationsCoxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1Structural Basis for L-Lysine Feedback Inhibition of Homocitrate SynthaseStructural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers,The Structural Basis of Endocannabinoid Oxygenation by Cyclooxygenase-2Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVECyclooxygenase-2 and cancer treatment: understanding the risk should be worth the rewardTherapies targeting lipid peroxidation in traumatic brain injuryConservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics.Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentationAsymmetric acetylation of the cyclooxygenase-2 homodimer by aspirin and its effects on the oxygenation of arachidonic, eicosapentaenoic, and docosahexaenoic acids.Dimerization of human 5-lipoxygenase.Prostaglandins and inflammation.GPIHBP1, an endothelial cell transporter for lipoprotein lipase.Biomarkers for personalizing omega-3 fatty acid dosing.Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism.The structure of ibuprofen bound to cyclooxygenase-2.A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase.Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.Human cyclooxygenase-1 activity and its responses to COX inhibitors are allosterically regulated by nonsubstrate fatty acids.Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activatorIntestinal smooth muscle dysfunction develops postnatally in cystic fibrosis miceDifferent Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis.Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.Biochemistry and pathophysiology of intravascular and intracellular lipolysis.Eicosanoids in metabolic syndrome.Major urinary metabolites of 6-keto-prostaglandin F2α in mice.Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2.Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin productionSubstrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide TonePre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.Mechanistic and pharmacological issues of aspirin as an anticancer agent.Prostaglandin H synthase: resolved and unresolved mechanistic issues.
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Cyclooxygenase Allosterism, Fatty Acid-mediated Cross-talk between Monomers of Cyclooxygenase Homodimers.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 12 February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Cyclooxygenase Allosterism, Fa ...... of Cyclooxygenase Homodimers.
@en
Cyclooxygenase Allosterism, Fa ...... of Cyclooxygenase Homodimers.
@nl
type
label
Cyclooxygenase Allosterism, Fa ...... of Cyclooxygenase Homodimers.
@en
Cyclooxygenase Allosterism, Fa ...... of Cyclooxygenase Homodimers.
@nl
prefLabel
Cyclooxygenase Allosterism, Fa ...... of Cyclooxygenase Homodimers.
@en
Cyclooxygenase Allosterism, Fa ...... of Cyclooxygenase Homodimers.
@nl
P2093
P2860
P356
P1476
Cyclooxygenase Allosterism, Fa ...... of Cyclooxygenase Homodimers.
@en
P2093
Chong Yuan
Dmitry V Kuklev
Inseok Song
Masayuki Wada
Ranjinder S Sidhu
William L Smith
P2860
P304
10046-10055
P356
10.1074/JBC.M808634200
P407
P577
2009-02-12T00:00:00Z