Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.
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Chapter 7: PharmacogenomicsSelectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenaseMolecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxenDifferential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acidInduction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugsReceptors involved in mechanical responses to catecholamines in the circular muscle of guinea-pig stomach treated with meclofenamateEnhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan importRole of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2The kinetic factors that determine the affinity and selectivity for slow binding inhibition of human prostaglandin H synthase 1 and 2 by indomethacin and flurbiprofenA three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitorsCharacterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase InhibitorThe role of prostaglandin synthesis in prostate cancer.Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products.A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirinNonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase 2, and fever.Selective inhibition of fatty acid oxidation in colonocytes by ibuprofen: a cause of colitis?Mechanistic insights into a classic wonder drug--aspirin.Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells.Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents.Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding ModeLeukotriene D4 receptors are not negatively coupled to adenylyl cyclase in guinea-pig lung parenchyma.Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia.Human cyclooxygenase-1 activity and its responses to COX inhibitors are allosterically regulated by nonsubstrate fatty acids.Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglandin H synthase-1.The use of quantum chemistry in pharmaceutical research as illustrated by case studies of indometacin and carbamazepine.The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 InhibitorInteractions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2.Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.Testing the "read-across hypothesis" by investigating the effects of ibuprofen on fishThe influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivativesRole of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents.Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.The eicosanoids and their biochemical mechanisms of action.The anti-inflammatory compound palmitoylethanolamide inhibits prostaglandin and hydroxyeicosatetraenoic acid production by a macrophage cell lineCholesterol expels ibuprofen from the hydrophobic membrane core and stabilizes lamellar phases in lipid membranes containing ibuprofen.In Silico Screening of Nonsteroidal Anti-Inflammatory Drugs and Their Combined Action on Prostaglandin H Synthase-1.Initiation of lipid peroxidation in biological systems.Eicosanoids and health.Lack of effect of leukotriene D4 on Ca-uptake in airway smooth muscle.
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Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on December 1975
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Structural requirements for ti ...... is by anti-inflammatory drugs.
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Structural requirements for ti ...... is by anti-inflammatory drugs.
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type
label
Structural requirements for ti ...... is by anti-inflammatory drugs.
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Structural requirements for ti ...... is by anti-inflammatory drugs.
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prefLabel
Structural requirements for ti ...... is by anti-inflammatory drugs.
@en
Structural requirements for ti ...... is by anti-inflammatory drugs.
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P2860
P356
P1476
Structural requirements for ti ...... is by anti-inflammatory drugs.
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P2093
P2860
P304
P356
10.1073/PNAS.72.12.4863
P407
P577
1975-12-01T00:00:00Z