Antisense reduction of tau in adult mice protects against seizures
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Community structure analysis of transcriptional networks reveals distinct molecular pathways for early- and late-onset temporal lobe epilepsy with childhood febrile seizuresInhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus.Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in MiceRNA-targeted Therapeutics for ALSAlphaScreen HTS and live-cell bioluminescence resonance energy transfer (BRET) assays for identification of Tau-Fyn SH3 interaction inhibitors for Alzheimer disease.Seizure resistance without parkinsonism in aged mice after tau reductionTau protein is essential for stress-induced brain pathologyHyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment.Tau association with synaptic vesicles causes presynaptic dysfunction.Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.Antisense-mediated Exon Skipping Decreases Tau Protein Expression: A Potential Therapy For TauopathiesMotor and cognitive deficits in aged tau knockout mice in two background strains.Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice.Tau reduction prevents disease in a mouse model of Dravet syndromePro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulationTau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease.Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicityNetwork dysfunction in α-synuclein transgenic mice and human Lewy body dementia.Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expressionMechanisms of tau and Aβ-induced excitotoxicity.Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathyRiluzole rescues alterations in rapid glutamate transients in the hippocampus of rTg4510 mice.Generation of a new transgenic mouse model for assessment of tau gene silencing therapies.Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model.Clinical trials: past, current, and future for atypical Parkinsonian syndromes.Invited review: Drug development for tauopathies.Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.The C-terminus of tau protein plays an important role in its stability and toxicity.Therapeutic Strategies for Restoring Tau Homeostasis.Epileptic activity in Alzheimer's disease: causes and clinical relevance.Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases.One Mutation Deserves Another in the Quest for Antiepileptogenesis.Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice.Low Cost Electrode Assembly for EEG Recordings in Mice.Epilepsy in patients with Alzheimer's disease: A systematic review.Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice.
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Antisense reduction of tau in adult mice protects against seizures
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Antisense reduction of tau in adult mice protects against seizures
@en
Antisense reduction of tau in adult mice protects against seizures.
@nl
type
label
Antisense reduction of tau in adult mice protects against seizures
@en
Antisense reduction of tau in adult mice protects against seizures.
@nl
prefLabel
Antisense reduction of tau in adult mice protects against seizures
@en
Antisense reduction of tau in adult mice protects against seizures.
@nl
P2093
P2860
P1476
Antisense reduction of tau in adult mice protects against seizures
@en
P2093
C Frank Bennett
Carey S Kebodeaux
David F Wozniak
Dorothy R Schuler
Dustin K Goncharoff
Floy R Stewart
Frank Rigo
John R Cirrito
Kaoru Yamada
P2860
P304
12887-12897
P356
10.1523/JNEUROSCI.2107-13.2013
P407
P577
2013-07-01T00:00:00Z