The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.
about
The structural basis of arrestin-mediated regulation of G-protein-coupled receptorsPhysiology of the orexinergic/hypocretinergic system: a revisit in 2012OX1 and OX2 orexin/hypocretin receptor pharmacogeneticsDynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptorPolarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse.beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity.Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cellsOrexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons.G-protein-coupled receptor phosphorylation: where, when and by whom.Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes.β-Arrestin-mediated receptor trafficking and signal transductionArrestin development: emerging roles for beta-arrestins in developmental signaling pathwaysOrexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress.Different downstream signalling of CCK1 receptors regulates distinct functions of CCK in pancreatic beta cellsLocation, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling.β-Arrestins in the immune systemOrexin/hypocretin receptor signalling cascades.The orexin OX(1) receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands.Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.Multiple roles for the C-terminal tail of the chemokine scavenger D6.Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function.Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.Molecular determinants of orexin receptor-arrestin-ubiquitin complex formation.Arachidonic acid release mediated by OX1 orexin receptors.Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms.Optogenetic examination identifies a context-specific role for orexins/hypocretins in anxiety-related behavior.Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics.Orexin/Hypocretin Signaling.Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line.Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors.The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases.
P2860
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P2860
The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The sustainability of interact ...... netics of ERK MAPK regulation.
@en
type
label
The sustainability of interact ...... netics of ERK MAPK regulation.
@en
prefLabel
The sustainability of interact ...... netics of ERK MAPK regulation.
@en
P2093
P2860
P356
P1433
P1476
The sustainability of interact ...... netics of ERK MAPK regulation.
@en
P2093
Graeme Milligan
Laura Ormiston
Nicholas A Evans
Robert J Lefkowitz
Sandra Milasta
Shelagh Wilson
P2860
P304
P356
10.1042/BJ20041745
P407
P577
2005-05-01T00:00:00Z