Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians - Wikidata - awgldk - TriplyDB

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

http://www.wikidata.org/entity/Q24676047

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Very important pharmacogene summary: thiopurine S-methyltransferase Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity A health-care system perspective on implementing genomic medicine: pediatric acute lymphoblastic leukemia as a paradigm Using germline genomics to individualize pediatric cancer treatments Structural basis of allele variation of human thiopurine-S-methyltransferase Pharmacogenomics in Pediatric Oncology: Review of Gene-Drug Associations for Clinical Use Personalization of the immunosuppressive treatment in renal transplant recipients: the great challenge in "omics" medicine NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity Pharmacogenomics: the promise of personalized medicine Genetic polymorphisms of human flavin-containing monooxygenase 3: implications for drug metabolism and clinical perspectives Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A, *3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositus Pharmacogenomic discovery using cell-based models Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics Genes implicated in thiopurine-induced toxicity: Comparing TPMT enzyme activity with clinical phenotype and exome data in a paediatric IBD cohort.Pharmacogenomics. Interview by Clare Thompson Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure.Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity.Pharmacogenetics of cancer therapy: getting personal Clinically relevant genetic variations in drug metabolizing enzymes.Pharmacogenomics: marshalling the human genome to individualise drug therapy Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population.Thiopurine S-methyltransferase genetic polymorphism in the Thai population Phenotyping and genotyping study of thiopurine S-methyltransferase in healthy Chinese children: a comparison of Han and Yao ethnic groups Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine.Pharmacogenetics and diseases of the colon.High-resolution melting analysis of the TPMT gene: a study in the Polish population.Pharmacogenomics in pediatric leukemia.Nomenclature for alleles of the thiopurine methyltransferase gene.Pharmacogenetics of drug metabolizing enzymes and transporters: effects on pharmacokinetics and pharmacodynamics of anticancer agents.TPMT*26 (208F-->L), a novel mutation detected in a Chinese.Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity.Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia.TPMT genetic variations in populations of the Russian Federation.Advances in the diagnosis and management of inflammatory bowel disease: challenges and uncertainties.Part 1: background, methodology, and clinical adoption of pharmacogenetics.Part 3: Pharmacogenetic variability in phase II anticancer drug metabolism.One amino acid makes a difference-Characterization of a new TPMT allele and the influence of SAM on TPMT stability.Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population.Comparison of Direct Sequencing, Real-Time PCR-High Resolution Melt (PCR-HRM) and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) Analysis for Genotyping of Common Thiopurine Intolerant Variant Alleles NUDT15 c.415C>T and TPMT c.719A>G (TPMT

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P2860

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

http://www.wikidata.org/entity/Q24676047

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1996 nî lūn-bûn

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1996 թվականի ապրիլին հրատարակված գիտական հոդված

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1996年の論文

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Protein measurement with the Folin phenol reagent

Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae

Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.

The purine path to chemotherapy.

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thiopurine S-methyltransferase deficiency

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