Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT
about
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signalingProtein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylationHistidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpLLoss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice.A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFATStructural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxinRegulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zetaLAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathwaysLeukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytesThe C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifThe SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotesAssociation of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinaseExpression of GADS enhances FLT3-induced mitogenic signaling.Quantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K.Competition between SLP76 and LAT for PLCĪ³1 binding in resting T cells.T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cellsGrap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.The role of Gads in hematopoietic cell signalling.MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT.CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling.Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor.Expression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony-stimulating factor stimulation.Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases.Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells.Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membraneProteome analysis reveals caspase activation in hyporesponsive CD4 T lymphocytes induced in vivo by the oral administration of antigen.Molecular mechanisms underlying the evolution of the slp76 signalosome.Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virusSin: good or bad? A T lymphocyte perspective.The transmembrane adapter LAT plays a central role in immune receptor signalling.The role of the adapter molecule SLP-76 in platelet function.Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathwaysEarly phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways.Signalling scaffolds and adaptors in T-cell immunity.Positive and negative regulation of T-cell activation by adaptor proteins.Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells
P2860
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P2860
Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT
description
1999 nĆ® lÅ«n-bĆ»n
@nan
1999 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕ”ÕµÕ«Õ½Õ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
Õ¤ÕøÖÕ”Õ®
@hyw
1999 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ“Õ”ÕµÕ«Õ½Õ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
1999幓ć®č«ę
@ja
1999幓č«ę
@yue
1999幓č«ę
@zh-hant
1999幓č«ę
@zh-hk
1999幓č«ę
@zh-mo
1999幓č«ę
@zh-tw
1999幓č®ŗę
@wuu
name
Grf40, A novel Grb2 family mem ...... nteraction with SLP-76 and LAT
@ast
Grf40, A novel Grb2 family mem ...... nteraction with SLP-76 and LAT
@en
Grf40, A novel Grb2 family mem ...... nteraction with SLP-76 and LAT
@nl
type
label
Grf40, A novel Grb2 family mem ...... nteraction with SLP-76 and LAT
@ast
Grf40, A novel Grb2 family mem ...... nteraction with SLP-76 and LAT
@en
Grf40, A novel Grb2 family mem ...... nteraction with SLP-76 and LAT
@nl
prefLabel
Grf40, A novel Grb2 family mem ...... nteraction with SLP-76 and LAT
@ast
Grf40, A novel Grb2 family mem ...... nteraction with SLP-76 and LAT
@en
Grf40, A novel Grb2 family mem ...... nteraction with SLP-76 and LAT
@nl
P2093
P2860
P3181
P356
P1476
Grf40, A novel Grb2 family mem ...... nteraction with SLP-76 and LAT
@en
P2093
K Sugamura
S Tsuchiya
T Takeshita
P2860
P304
P3181
P356
10.1084/JEM.189.9.1383
P407
P577
1999-05-03T00:00:00Z